This page describes pharmacological agents that may have legal restrictions, side effects, and drug interactions in your jurisdiction. Information is for educational research only — consult a clinician before considering any compound.
Fluoxetine
Original SSRI (1987).
Aliases (2)
Overview
What is Fluoxetine?
Fluoxetine (Prozac) is the prototype SSRI, FDA-approved in 1987 for major depression. Indications now include OCD, bulimia, panic disorder, and PMDD. Long half-life (active metabolite norfluoxetine ~7-15 days).
Key Benefits
Effective for depression, OCD, bulimia, PMDD, and panic disorder. Long half-life buffers missed doses and reduces discontinuation syndrome. Safe in overdose vs older antidepressants.
Mechanism of Action
Selectively inhibits the serotonin transporter (SERT), increasing synaptic serotonin. Mild 5-HT2C antagonism contributes to slight noradrenergic and dopaminergic disinhibition. Active metabolite extends pharmacology.
Pharmacokinetics
What to Expect
- Week 1Tolerability and dose-response.
- Week 2-4Early effect window.
- Week 4-8Peak benefit assessment.
- Week 8+Cycle decision point.
Side Effects & Safety
- Common (>10%): Nausea, headache, insomnia, sexual dysfunction (40-70%), anxiety/jitteriness early.
- Less common (1-10%): Weight loss early, weight gain long-term, tremor, sweating, anorgasmia.
- Rare-serious (<1%): Serotonin syndrome, hyponatremia, suicidal ideation <25 yo (FDA black box), QT prolongation at high doses.
- Specific watch periods: First 4 weeks for activation/suicidal ideation; long half-life means drug interactions persist 5+ weeks after stopping.
References
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