This page describes pharmacological agents that may have legal restrictions, side effects, and drug interactions in your jurisdiction. Information is for educational research only — consult a clinician before considering any compound.
Arginine
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Deeper analysis, verdict reasoning, and per-archetype recommendations from our research team.
▸ Editor's verdict OTHER HIGH
"Oral L-arginine has poor bioavailability (~20-30% in adults) due to extensive first-pass hepatic + intestinal arginase metabolism — most never reaches systemic circulation to support eNOS. L-citrulline (especially citrulline-malate) bypasses this and produces higher plasma arginine AUC than equimolar arginine itself. Unless using IV arginine for clinical NO testing or specific cardiovascular indications, citrulline-malate is the strictly superior fork for an MMA athlete targeting blood flow / pump / endurance. Skip arginine; redirect to citrulline-malate."
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Anonymous · one vote per session · results below at 5+ votes.
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