This page describes pharmacological agents that may have legal restrictions, side effects, and drug interactions in your jurisdiction. Information is for educational research only — consult a clinician before considering any compound.

Compact view
Research pass: thorough Compound SKIP-FOR-NOW HIGH

Roxadustat

Extended Research
High-risk compound

Surface here is educational only; do not use without medical supervision. Our editorial verdict is SKIP-FOR-NOW — current cost / risk / redundancy puts it below the line.

Extended Research

Our depth — beyond the mirror

Deeper analysis, verdict reasoning, and per-archetype recommendations from our research team.

Editor's verdict SKIP-FOR-NOW HIGH

Triple-disqualifier for this user. **(1) No clinical indication** — 20yo MMA athlete with no anemia, no CKD, normal Hb/Hct/iron panel; this drug is built to fix renal failure-driven hypo-erythropoiesis, not enhance physiology. **(2) FDA rejected on cardiovascular safety** — CRDAC 13-1/12-2 votes citing thrombosis (vascular access thrombosis RR 1.5, DVT RR 3.9 in DD-CKD; seizures, infections, MACE signal in NDD-CKD), Complete Response Letter Aug 2021, AstraZeneca walked away from US rights entirely. The endurance gain athletes seek (raising hematocrit) is exactly the mechanism that drove the thrombotic events that killed the FDA filing — combat sports already raise stroke risk via head impact, and a young athlete stacking hematocrit on top of subconcussive trauma is moving the wrong direction on the risk curve. **(3) WADA-banned in and out of competition.** Even if he were tested at the amateur MMA level today, sanctioned competition (USA Boxing, USADA-tested events, future pro license) would catch detectable metabolites for ~30+ days post-dose; multiple positive cases on record (Simona Halep 2022, several cyclists, equine doping). The legitimate altitude-adaptation analog is **actually train at altitude or use a hypoxic tent** — same HIF stabilization, no thrombosis signal, no anti-doping risk, no $300+/month gray-market exposure. Would only revisit if he developed a documented anemia of CKD (extremely unlikely at 20) AND moved to a jurisdiction with EU/Japan/China approval AND obtained legitimate prescription. None of those are imminent.

Research pass: thorough
Biomarkers to track (deep)

Pre-cycle: CBC with diff (Hb, Hct, RBC, MCV, RDW), iron studies (serum Fe, TIBC, ferritin, TSAT), serum EPO, BUN, creatinine, eGFR, electrolytes (especially K), LFTs (ALT, AST), fasting lipids, fasting glucose, BP log over 1 week, ECG.

On-cycle (every 2 weeks): CBC, iron panel, BP. Watch for Hb climbing past target.

Post-cycle: full panel + retic count, hepcidin if available (research-only assay in US).

How was your experience with this compound?

Anonymous · one vote per session · results below at 5+ votes.

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