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Ashwagandha Sensoril
Root + leaf ashwagandha extract standardized to ~10% withanolides, licensed by Natreon (US-based), and the substrate of the strongest sleep + anxiety trials in the ashwagandha literature.
Aliases (4)
Overview
What is Ashwagandha Sensoril?
Sensoril is a root + leaf ashwagandha extract standardized to a higher 10% withanolide content, developed by Natreon. It has a different withanolide profile from KSM-66 (more withanolide A, withaferin A) and is more sedating, often preferred for sleep and acute stress relief.
Key Benefits
More pronounced stress and anxiety relief than KSM-66, better sleep onset and quality, useful as evening dose; less emphasized for testosterone and exercise performance.
Mechanism of Action
Higher concentration of withaferin A and withanolide A confers stronger GABAergic and HPA-modulating action than KSM-66, along with similar antioxidant and anti-inflammatory effects. Trade-off: more sedating, less daytime-friendly.
Pharmacokinetics
Peptide Interactions
Compound sleep-architecture support — but the user already has these
(the canonical stack): GABAergic + Mg synergy
(the canonical stack): AM-rhodiola + PM-Sensoril is a sensible adaptogen split
(the canonical stack): Additive evening calm
(benzos, alcohol, high-dose THC, melatonin >5 mg): Compound sedation
see parent
What to Expect
- Week 1Tolerability and dose-response.
- Week 2-4Early effect window.
- Week 4-8Peak benefit assessment.
- Week 8+Cycle decision point.
Side Effects & Safety
Same as parent. Sensoril-specific notes:
- Higher withaferin A → slightly higher theoretical autoimmune flare risk; case reports rare but Sensoril-associated
- Daytime drowsiness if dosed AM
- Hepatotoxicity case reports more often associated with Sensoril than KSM-66 (still rare; possibly publication bias from Sensoril's earlier market presence)
- "Vivid dreams" common at higher PM doses
References
Auddy et al. 2008 — Sensoril chronic stress, dose-ranging trial (JANA)
Deshpande et al. 2020 — Sensoril 120 mg sleep RCT (Sleep Med)
Pingali et al. 2014 — Sensoril cognitive RCT (Pharmacognosy Res)
How was your experience with this compound?
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