◈ Nootpedia

This page describes pharmacological agents that may have legal restrictions, side effects, and drug interactions in your jurisdiction. Information is for educational research only — consult a clinician before considering any compound.

Browse

B7-33

needs-research

TYPICAL DOSE
—
ROUTE
—
CYCLE
—
STORAGE
—

Overview

What is B7-33?

>

>TGN1412 (also known as CD28-SuperMAB) is the working name of an immunomodulatory drug which was withdrawn from development after inducing severe inflammatory reactions in the first-in-man study in London in March 2006. The developing company, TeGenero Immuno Therapeutics, entered into insolvency proceedings later that year.

>Originally intended for the treatment of B cell [chronic lymphocytic leukemia](https://en.wikipedia.or"

These are the collection of potential routes to the lysergic skeleton I've come up with.
Apart from the last two, they're variants of a coupling of cyclised tryptophan derivative 1, with a 4-carbon fragment (a methacrylic derivative);
or with a 3-carbon allylic/bromoacetone fragment (with the carboxy unit added later).
The electrophilic (right) end reacts with the NH2, while the nucleophilic left end reacts with the C=O group.
Derivative 1 is made by reacting tryptophan (or its alkyl ester) with pivaloyl or triisopropylsilyl (TIPS) chloride, and AlCl3 (to protect the amine).
The steric bulk of TIPS makes attack on the indole ring unfavorable, and might make it reversible at long reaction times. TIPS is deprote"

Dad is a heart patient, this is his current stack. He feels incredible. He’s taking this along with his other Dr. prescribed meds."

Now, before trying cerebrolysin, think about studying up on Dr. Terry Wahl's solution. She was an MS patient herself and completely healed herself. She has many talks TEDeX and other youtubes. Here are some of here links. Please keep us posted.

https://terrywahls.com/start/

How I Went From Wheelchair To Walking By Changing My Diet: Dr. Terry Wahls [https://terrywahls.com/mi"

B1: Thiamin

B2: Riboflavin

B3: niacin

B5: Pantothenic acid

B6: pyridoxine

B7/B8: Biotin

B9: Folate

B12: cobalamin

These are all very common in b complex bottles. Try Country Life Coenzyme B-Complex Caps."

Researchers found that although people from each country had different gut bacteria, all those with Parkinson’s had fewer bacteria that make vitamins B2 (riboflavin) and B7 (biotin).

The researchers suggest that this could contribute to neuroinflammation and that supplementation with these vitamins may be beneficial for some people with the condition."

This is for a few reasons:

  1. salmonella risk although washing your eggs probably negates this

  2. Eggs contain a protein called avidin that has a very strong binding affinity for biotin (vitamin B7) and eating a lot of raw eggs can cause biotin absorption issues leading to a biotin deficiency. However cooking (or pasteurising) the eggs denatures avidin making it a non-issue

  3. protein from eggs is some of the best you can get from an amino acid profile stand point. Cooking your eggs makes the protein more bioavailable/easier to absorb.

I love my eggs and eat a minimum of 6 a day but if my calorie needs allow it I regularly eat 8 or even 12 in a day. But eat them cooked is my advice"

High B1 - Water soluble and should be excreted. I think nausea is possible but it's rare

Low B1 - Causes numerous problems, irritability, confusion, fatigue, eventual brain damage, it's unlikely you have low B1 though unless you're an alcoholic, or have an eating disorder, dieting. Or maybe something that is preventing its absorption

High B2 - water soluble and excess is excreted. No symptoms.

Low B2 causes fatigue, depression, and anxiety, among other physical stuff.

High B3 can cause flushing, head ache, liver toxicity

Low B3 can cause fatigue and abdominal pain, loss of appetite

High B5 - No symptoms as far as I know

Low B5 - I think this is extremely rare and unlikely

Very High B6 - Periphe"

> Soybean Oil, Gelatin, Dibasic Calcium Phosphate, Glycerin, Yellow Beeswax, Water, Colors Added, Soy Lecithin, Resin.NiacinVitamin B6Folic AcidVitamin B12Biotin (B7)Pantothenic Acid"

I have both whats considered Osmotic demyelination syndrome and Onleys lesions from malpractice. Nothing from concussive injuries.

1. 2. 3.

If we're talking about the magnitude of severe TBI, As far as our research shows to the best of my knowledge what happens in TBI is that excessive stress/damage induces senescence in brain tissue, whi"

I posted this earlier today actually but nobody responded so I'll just copy it below. There could perhaps be some other supplements I should take I think possibly choline looking at my recommendations from dna sequencing but everything else is covered. But this is just me though everyone's different and someone else witg similar symptoms may require different supplements than me.

"The health supplements, protein shake and multivitamin I take contains the following ingredients which I take daily.

A, B1, B2, B3, B5, B6, B7, B9, B12, C, D, E, K1, calcium, chromium iron, iodine, copper, magnesium,"

  • sourceThread: "r/Nootropics" permalink: "https://www.reddit.com/r/Nootropics/comments/3gdri0/_/ctxjft5" score: 4 createdAt: "2015-08-10T02:33:51Z" authorHandle: "3d758fba" isOriginalPoster: false isPostBody: false postTitle: null wordCount: 463 excerpt: "No, it doesn't have a "phenethylamine backbone". Phenethylamine is a benzene ring with an ethyl group and an amine on the tail end.

Phenylpiracetam has a phenyl group, but it's connected to just a plain old racetam molecule, which has a 2-Pyrrolidinone nucleus. Yeah, the racetam part of phenypiracetam has an amine at the far end, but the shape of the molecule is totally different. I think what you are seeing is this , which I higlighted in red. I rotated the phenethylamine skeletal structure to be oriented more like phenylpiracetam's. However, it's misleading because in phenethylamine the skeleton of ethyl groups is coming straight off more or less, which you can see in the 3D filled model of phenethylamine [here](https://upload.wikimedia.org/wikipedia/c"

  • sourceThread: "r/Nootropics" permalink: "https://www.reddit.com/r/Nootropics/comments/16a1j2/_/c7ua7eu" score: 4 createdAt: "2013-01-10T05:27:09Z" authorHandle: "03cb838f" isOriginalPoster: false isPostBody: false postTitle: null wordCount: 169 excerpt: "Nothing is really absorbed in the stomach, just broken down. We don't really want any of our racetams to be broken down, but absorbed as is. Most of the supplements we are concerned with are going to be absorbed in the small intestine. Some vitamins like B7 and K will be absorbed in the large intestine. Protecting them from acids and stomach enzymes till they get there is always good. Some substances are fat soluble, so they should be taken with some sort of oil, like fish oil, soy lecithin, flaxseed oil, etc.

Pretty much any of the racetams should be taken on an empty stomach. The water soluble ones alone, the lipid soluble ones with some oil. Capsuling is always a good idea, so there is at least some protection from stomach acids. Some of the racetams are going to be more susceptible t"

Let's assume you can make and isolate the pure tricyclic precursor; it definitely seems plausible.

Route A: Right off the bat the SN2 alkylation with a primary amine is a poor choice. The secondary amine formed after the first alkylation is more nucleophilic than the original primary, and double alkylation is inevitable. Your drawn product would be a minor product, and be a PITA to purify. The authors you referenced used an N-methylated compound to overcome this. To fix this with your path, you'd need to pull off a monomethylation of tryptamine, which I imagine isn't fun. It's a crapshoot as"

  • sourceThread: "r/StackAdvice" permalink: "https://www.reddit.com/r/StackAdvice/comments/glrooz/college_and_testosterone_stack/fr02uyq/" score: 4 createdAt: "2020-05-18T06:08:35Z" authorHandle: "a5fc6d5d" isOriginalPoster: false isPostBody: false postTitle: null wordCount: 207 excerpt: "Never take choline like that long term. Food sources only. Raw egg yolks, peanut butter, peanut butter powder or liver. I drink 2-3 raw eggs in orange juice with turmeric every day. It’s excellent for mental energy and has a slow release sort of effect. It will also support the next supplement I will recommend, acetylcarnitine. Alcar increases testosterone receptor activity in your muscles.

While taking alcar you absolutely must consume a good source of omega 3s because it will deplete DHA and EPA. It also uses up biotin aka b7 so it’s a good idea to pop 5,000 mg of it every day. I like the chewable tabs. It’s never toxic, even in high doses.

Alcar can keep you from sleeping if you take it too late in the day so be mindful of that. If you take one 500 mg pill in the morning, you can pr"

  • sourceThread: "r/Biohackers" permalink: "https://www.reddit.com/r/Biohackers/comments/112neq4/essential_vitamins_and_supplements_stack/j8nfkh7/" score: 4 createdAt: "2023-02-15T16:27:56Z" authorHandle: "eb30340a" isOriginalPoster: false isPostBody: false postTitle: null wordCount: 247 excerpt: "Essential vitamins and minerals are nutrients that our bodies require in small amounts for optimal health and functioning. They are essential because our bodies cannot produce them on their own, so we need to get them through our diet or supplements.

Some of the essential vitamins include:

Vitamin A: important for vision, immune system, and cell growth and differentiation

Vitamin C: important for immune system, skin health, and wound healing

Vitamin D: important for bone health, immune system, and calcium absorption

Vitamin E: important for antioxidant functions and cell membrane stability

Vitamin K: important for blood clotting and bone health

Vitamin B complex (B1, B2, B3, B5, B6, B7, B9, and B12)

Minerals:

Calcium: helps with bone and teeth health, muscle function, and nerve "

For VIP in EU you kan get it with suaway.com. B7-33 at the moment not, hopfully in future."

First of all eggs contain avidin that inhibits biotin (B7) absorption which in the end will lead to a deficiency if consumed regularly. Avidin is very easily destroyed by cooking the eggs.

Second of all, egg protein is not very absorbable in its raw state. around 50% of the protein is absorbed when raw, compared to 90-100% when it's cooked*. Cooking your eggs will eliminate all the problems eggs can have and therefore i don't see the reason why not to cook them. *https://authoritynutrition.com/eating-raw-eggs/

furthermore I see some of you are discussing the risk of salmonella from raw eggs. It really depends on where you live in this world. in Scandinavia where i live no eggs carry salmonella anymore, but it could be a riskfactor if you live e" attribution: sources: - name: "dopamine.club" role: "community aggregate stats, dose distribution, stack synergies, AI-seeded interactions" url: "https://dopamine.club/substances/b7-33/" - name: "reddit" role: "paragraph-level community anecdotes" url: "https://reddit.com" text: "Aggregated from creator-curated and community sources. Verify dose, sourcing, and safety before use."

=== community-data-block:end ===

>

>TGN1412 (also known as CD28-SuperMAB) is the working name of an immunomodulatory drug which was withdrawn from development after inducing severe inflammatory reactions in the first-in-man study in London in March 2006. The developing company, TeGenero Immuno Therapeutics, entered into insolvency proceedings later that year.

>Originally intended for the treatment of B cell [chronic lymphocytic leukemia](https://en.wikipedia.or"

These are the collection of potential routes to the lysergic skeleton I've come up with.
Apart from the last two, they're variants of a coupling of cyclised tryptophan derivative 1, with a 4-carbon fragment (a methacrylic derivative);
or with a 3-carbon allylic/bromoacetone fragment (with the carboxy unit added later).
The electrophilic (right) end reacts with the NH2, while the nucleophilic left end reacts with the C=O group.
Derivative 1 is made by reacting tryptophan (or its alkyl ester) with pivaloyl or triisopropylsilyl (TIPS) chloride, and AlCl3 (to protect the amine).
The steric bulk of TIPS makes attack on the indole ring unfavorable, and might make it reversible at long reaction times. TIPS is deprote"

Dad is a heart patient, this is his current stack. He feels incredible. He’s taking this along with his other Dr. prescribed meds."

Now, before trying cerebrolysin, think about studying up on Dr. Terry Wahl's solution. She was an MS patient herself and completely healed herself. She has many talks TEDeX and other youtubes. Here are some of here links. Please keep us posted.

https://terrywahls.com/start/

How I Went From Wheelchair To Walking By Changing My Diet: Dr. Terry Wahls [https://terrywahls.com/mi"

B1: Thiamin

B2: Riboflavin

B3: niacin

B5: Pantothenic acid

B6: pyridoxine

B7/B8: Biotin

B9: Folate

B12: cobalamin

These are all very common in b complex bottles. Try Country Life Coenzyme B-Complex Caps."

Researchers found that although people from each country had different gut bacteria, all those with Parkinson’s had fewer bacteria that make vitamins B2 (riboflavin) and B7 (biotin).

The researchers suggest that this could contribute to neuroinflammation and that supplementation with these vitamins may be beneficial for some people with the condition."

This is for a few reasons:

  1. salmonella risk although washing your eggs probably negates this

  2. Eggs contain a protein called avidin that has a very strong binding affinity for biotin (vitamin B7) and eating a lot of raw eggs can cause biotin absorption issues leading to a biotin deficiency. However cooking (or pasteurising) the eggs denatures avidin making it a non-issue

  3. protein from eggs is some of the best you can get from an amino acid profile stand point. Cooking your eggs makes the protein more bioavailable/easier to absorb.

I love my eggs and eat a minimum of 6 a day but if my calorie needs allow it I regularly eat 8 or even 12 in a day. But eat them cooked is my advice"

High B1 - Water soluble and should be excreted. I think nausea is possible but it's rare

Low B1 - Causes numerous problems, irritability, confusion, fatigue, eventual brain damage, it's unlikely you have low B1 though unless you're an alcoholic, or have an eating disorder, dieting. Or maybe something that is preventing its absorption

High B2 - water soluble and excess is excreted. No symptoms.

Low B2 causes fatigue, depression, and anxiety, among other physical stuff.

High B3 can cause flushing, head ache, liver toxicity

Low B3 can cause fatigue and abdominal pain, loss of appetite

High B5 - No symptoms as far as I know

Low B5 - I think this is extremely rare and unlikely

Very High B6 - Periphe"

> Soybean Oil, Gelatin, Dibasic Calcium Phosphate, Glycerin, Yellow Beeswax, Water, Colors Added, Soy Lecithin, Resin.NiacinVitamin B6Folic AcidVitamin B12Biotin (B7)Pantothenic Acid"

I have both whats considered Osmotic demyelination syndrome and Onleys lesions from malpractice. Nothing from concussive injuries.

1. 2. 3.

If we're talking about the magnitude of severe TBI, As far as our research shows to the best of my knowledge what happens in TBI is that excessive stress/damage induces senescence in brain tissue, whi"

I posted this earlier today actually but nobody responded so I'll just copy it below. There could perhaps be some other supplements I should take I think possibly choline looking at my recommendations from dna sequencing but everything else is covered. But this is just me though everyone's different and someone else witg similar symptoms may require different supplements than me.

"The health supplements, protein shake and multivitamin I take contains the following ingredients which I take daily.

A, B1, B2, B3, B5, B6, B7, B9, B12, C, D, E, K1, calcium, chromium iron, iodine, copper, magnesium,"

  • sourceThread: "r/Nootropics" permalink: "https://www.reddit.com/r/Nootropics/comments/3gdri0/_/ctxjft5" score: 4 createdAt: "2015-08-10T02:33:51Z" authorHandle: "3d758fba" isOriginalPoster: false isPostBody: false postTitle: null wordCount: 463 excerpt: "No, it doesn't have a "phenethylamine backbone". Phenethylamine is a benzene ring with an ethyl group and an amine on the tail end.

Phenylpiracetam has a phenyl group, but it's connected to just a plain old racetam molecule, which has a 2-Pyrrolidinone nucleus. Yeah, the racetam part of phenypiracetam has an amine at the far end, but the shape of the molecule is totally different. I think what you are seeing is this , which I higlighted in red. I rotated the phenethylamine skeletal structure to be oriented more like phenylpiracetam's. However, it's misleading because in phenethylamine the skeleton of ethyl groups is coming straight off more or less, which you can see in the 3D filled model of phenethylamine [here](https://upload.wikimedia.org/wikipedia/c"

  • sourceThread: "r/Nootropics" permalink: "https://www.reddit.com/r/Nootropics/comments/16a1j2/_/c7ua7eu" score: 4 createdAt: "2013-01-10T05:27:09Z" authorHandle: "03cb838f" isOriginalPoster: false isPostBody: false postTitle: null wordCount: 169 excerpt: "Nothing is really absorbed in the stomach, just broken down. We don't really want any of our racetams to be broken down, but absorbed as is. Most of the supplements we are concerned with are going to be absorbed in the small intestine. Some vitamins like B7 and K will be absorbed in the large intestine. Protecting them from acids and stomach enzymes till they get there is always good. Some substances are fat soluble, so they should be taken with some sort of oil, like fish oil, soy lecithin, flaxseed oil, etc.

Pretty much any of the racetams should be taken on an empty stomach. The water soluble ones alone, the lipid soluble ones with some oil. Capsuling is always a good idea, so there is at least some protection from stomach acids. Some of the racetams are going to be more susceptible t"

Let's assume you can make and isolate the pure tricyclic precursor; it definitely seems plausible.

Route A: Right off the bat the SN2 alkylation with a primary amine is a poor choice. The secondary amine formed after the first alkylation is more nucleophilic than the original primary, and double alkylation is inevitable. Your drawn product would be a minor product, and be a PITA to purify. The authors you referenced used an N-methylated compound to overcome this. To fix this with your path, you'd need to pull off a monomethylation of tryptamine, which I imagine isn't fun. It's a crapshoot as"

  • sourceThread: "r/StackAdvice" permalink: "https://www.reddit.com/r/StackAdvice/comments/glrooz/college_and_testosterone_stack/fr02uyq/" score: 4 createdAt: "2020-05-18T06:08:35Z" authorHandle: "a5fc6d5d" isOriginalPoster: false isPostBody: false postTitle: null wordCount: 207 excerpt: "Never take choline like that long term. Food sources only. Raw egg yolks, peanut butter, peanut butter powder or liver. I drink 2-3 raw eggs in orange juice with turmeric every day. It’s excellent for mental energy and has a slow release sort of effect. It will also support the next supplement I will recommend, acetylcarnitine. Alcar increases testosterone receptor activity in your muscles.

While taking alcar you absolutely must consume a good source of omega 3s because it will deplete DHA and EPA. It also uses up biotin aka b7 so it’s a good idea to pop 5,000 mg of it every day. I like the chewable tabs. It’s never toxic, even in high doses.

Alcar can keep you from sleeping if you take it too late in the day so be mindful of that. If you take one 500 mg pill in the morning, you can pr"

  • sourceThread: "r/Biohackers" permalink: "https://www.reddit.com/r/Biohackers/comments/112neq4/essential_vitamins_and_supplements_stack/j8nfkh7/" score: 4 createdAt: "2023-02-15T16:27:56Z" authorHandle: "eb30340a" isOriginalPoster: false isPostBody: false postTitle: null wordCount: 247 excerpt: "Essential vitamins and minerals are nutrients that our bodies require in small amounts for optimal health and functioning. They are essential because our bodies cannot produce them on their own, so we need to get them through our diet or supplements.

Some of the essential vitamins include:

Vitamin A: important for vision, immune system, and cell growth and differentiation

Vitamin C: important for immune system, skin health, and wound healing

Vitamin D: important for bone health, immune system, and calcium absorption

Vitamin E: important for antioxidant functions and cell membrane stability

Vitamin K: important for blood clotting and bone health

Vitamin B complex (B1, B2, B3, B5, B6, B7, B9, and B12)

Minerals:

Calcium: helps with bone and teeth health, muscle function, and nerve "

For VIP in EU you kan get it with suaway.com. B7-33 at the moment not, hopfully in future."

First of all eggs contain avidin that inhibits biotin (B7) absorption which in the end will lead to a deficiency if consumed regularly. Avidin is very easily destroyed by cooking the eggs.

Second of all, egg protein is not very absorbable in its raw state. around 50% of the protein is absorbed when raw, compared to 90-100% when it's cooked*. Cooking your eggs will eliminate all the problems eggs can have and therefore i don't see the reason why not to cook them. *https://authoritynutrition.com/eating-raw-eggs/

furthermore I see some of you are discussing the risk of salmonella from raw eggs. It really depends on where you live in this world. in Scandinavia where i live no eggs carry salmonella anymore, but it could be a riskfactor if you live e" attribution: sources: - name: "dopamine.club" role: "community aggregate stats, dose distribution, stack synergies, AI-seeded interactions" url: "https://dopamine.club/substances/b7-33/" - name: "reddit" role: "paragraph-level community anecdotes" url: "https://reddit.com" text: "Aggregated from creator-curated and community sources. Verify dose, sourcing, and safety before use."

=== community-data-block:end ===

What to Expect

  • Week 1
    Tolerability and dose-response.
  • Week 2-4
    Early effect window.
  • Week 4-8
    Peak benefit assessment.
  • Week 8+
    Cycle decision point.
Was this helpful?
Your feedback shapes what we research deeper.

How was your experience with this compound?

Anonymous · one vote per session · results below at 5+ votes.

Loading…
✎

See something off?

Most of this wiki is AI-generated. Suggest a correction, dosing update, or new evidence — we review every submission.

Discussion — click to load ▸
Loading…
Continue: Extended research →
Our verdict, decision matrix, deep dives, controversies, sources