This page describes pharmacological agents that may have legal restrictions, side effects, and drug interactions in your jurisdiction. Information is for educational research only — consult a clinician before considering any compound.
Bromelain
Pineapple-stem proteolytic enzyme complex (cysteine proteases bromelain + ananain + comosain) with a real but B-tier anti-inflammatory profile — best-evidenced for post-surgical and post-traumatic …
Aliases (1)
Overview
What is Bromelain?
To prevent hypercholesterolemia for cheaper (and likely m"
- sourceThread: "r/Biohackers" permalink: "https://www.reddit.com/r/Biohackers/comments/1jgp8jz/whats_your_go_to_for_oh_no_i_may_be_getting_sick/mj160d2/" score: 11 createdAt: "2025-03-21T20:01:33Z" authorHandle: "08c8d39f" isOriginalPoster: false isPostBody: false postTitle: null wordCount: 56 excerpt: "Never got sick even during Covid!
-Raw garlic cloves in manuka honey
Irwin Naturals Pure Defense Mushroom-8 Immune
Clean Nutraceuticals NAC Supplement N-Acetyl Cysteine Vitamin D3 K2 Zinc Quercetin Sarracenia Purpurea with Elderberry Holy Basil Bee Propolis Bromelain L-Lysine
Propolis Throat Spray by Beekeeper's Naturals - 95% Bee Propolis Extract, Natural Immune Support
- sourceThread: "r/Nootropics" permalink: "https://www.reddit.com/r/Nootropics/comments/rwcajm/nac_helps_anxiety_depression_sleep_apnea_now_covid/hrbbx8r/" score: 10 createdAt: "2022-01-05T04:49:38Z" authorHandle: "5ccaff7b" isOriginalPoster: false isPostBody: false postTitle: null wordCount: 67 excerpt: "I've been doing a fairly regular stack of C, D3, Zinc, Quercetin, Bromelain, NAC, Mg and Melatonin for a few months. I got sick last week for the first time during the pandemic and was at 80% within 24 hours, 100% aside from lingering sniffle within 3 days.
Anecdotal, but definitely seemed to help. I upped the NAC, C and Quercetin doses when I started feeling symptoms."
- sourceThread: "r/Nootropics" permalink: "https://www.reddit.com/r/Nootropics/comments/vjnbqc/nootropics_ive_tried_for_brain_fog_ranked_long/idmmgb3/" score: 9 createdAt: "2022-06-25T00:07:18Z" authorHandle: "09c33016" isOriginalPoster: false isPostBody: false postTitle: null wordCount: 327 excerpt: "I can't believe the lack of public information on this topic. The medical community has given absolutely zero good actionable advice on this topic, demonstrating once again that mainstream medicine makes no basically no attempt to treat chronic illnesses which can't directly be tested for (unlike, e.g. multiple sclerosis). It's a bit criminal.
- Fibrinolytic drugs. Disordered (typically excessive) blood coagulation is a major aspect of long covid. Fibrinolytic drugs dissolve fibrin agglomerations, and commonly other related things like atherosclerotic plaques and amyloid beta deposits. They're amazing supplements, a must-try for long covid. [The cfsremission.com blog is where I learned about this; an incredible resource for all chronic illness sufferers](https://cfsremission.com/tr"
- sourceThread: "r/Nootropics" permalink: "https://www.reddit.com/r/Nootropics/comments/jtn26m/aspirin_for_cellular_respiration_and_youth/gc6rhuf/" score: 9 createdAt: "2020-11-13T20:33:49Z" authorHandle: "4db9b812" isOriginalPoster: false isPostBody: false postTitle: null wordCount: 122 excerpt: "I wonder how much of it was simply aspirin's anti-inflammatory effect, in which case you could try bromelain to avoid the deleterious effects from prolonged COX-1 inhibition.
Taking cortisone for a few days before an MRI made me realize how inflammed I was. Euphoric relief washed over my whole body. I had little idea what cortisone even was, had to look it up and find out it's an anti-inflammatory. Prior, I'd have simply reported feelings of fatigue, low mood, irritability, insomnia, that are always easy to accept as just a slump/phase (and could be explained by my real life situation at the time, lots of stress, dissatisfied, night shifts etc). I was able to find that same kind of relief in bromelain."
- sourceThread: "r/Nootropics" permalink: "https://www.reddit.com/r/Nootropics/comments/mrz9uo/quercetin_impairs_learning_and_memory_in_normal/gupzt0y/" score: 8 createdAt: "2021-04-16T13:26:53Z" authorHandle: "bf8333a2" isOriginalPoster: false isPostBody: false postTitle: null wordCount: 18 excerpt: "Probably bromelain, vitamin C and piperine/bioperine can improve the absorption.
Onion quercetin is better absorbed than apple quercetin"
- sourceThread: "r/StackAdvice" permalink: "https://www.reddit.com/r/StackAdvice/comments/11rkjxi/what_is_your_anti_inflamatory_stack_and_why/jc9pz3p/" score: 8 createdAt: "2023-03-15T08:35:41Z" authorHandle: "45e35081" isOriginalPoster: false isPostBody: false postTitle: null wordCount: 27 excerpt: "Quercetin and bromelain, Vitamin K and D, astaxanthan, fish oil, turmeric, boron, msm, and coq10.
I have osteoarthritis and this combo has been helping with the pain."
- sourceThread: "r/Nootropics" permalink: "https://www.reddit.com/r/Nootropics/comments/106bsnp/going_off_of_my_nootropics_almost_killed_me/j3len62/" score: 6 createdAt: "2023-01-09T10:58:18Z" authorHandle: "395591f8" isOriginalPoster: false isPostBody: false postTitle: null wordCount: 134 excerpt: "I'll second how effective Quercetin is for inhibiting histamine.
I've been using it for 3 months with very good results and, usually, kicks in within 15-20 mins.
I had been searching for something to replace OTC anti-histamine drugs as they make me so drowsy and, basically, unproductive for half to a full day (probably removing too much histamine from the brain but idk).
Quercetin (with Bromelain) really works far better than I was expecting. I found L-theanine comes second to it but takes a little longer to kick in and I'm not certain it's as effective but still worth trying.
I've also read in a study (and I've lost the source now) that Cranberry increases Quercetin absorption (along with Bromelain and something fatty). I've tried them all but can't really vouch for increased effec"
- sourceThread: "r/Nootropics" permalink: "https://www.reddit.com/r/Nootropics/comments/rwcajm/nac_helps_anxiety_depression_sleep_apnea_now_covid/hrce84n/" score: 6 createdAt: "2022-01-05T12:02:05Z" authorHandle: "bd6d6bb2" isOriginalPoster: false isPostBody: false postTitle: null wordCount: 306 excerpt: "Sorry for my early morning gibberish. I'll try again, with some more detail:
I've only been with a few days of fever last month in the last 7 years. However, I forgotten how old I am (and how time flies), it's actually 9.5 years ago I had the flu, strep throat or the cold last.
Base stack (daily):
500mg ascorbyl palmitat (superior form of C-vit) - replaced ascorbic acid after I had developed two lipomas. AP has anti-tumor effects in fatty tissue, which is what lipomas are. One went away by itself, other got removed. None have re-emerged since.
High quality krill oil (1.5g EPA)
30mg zinc (with some cobber)
500mg Magnesium complex
125mcg D3 (with K-complex and iodine)
12mg astaxanthin
B-vit complex (every other day)
Bromelain 300mg / quercetin 1g - added to the stack after a pa"
- sourceThread: "r/Nootropics" permalink: "https://www.reddit.com/r/Nootropics/comments/brn7df/advil_helps_with_my_brain_fog/eofeqwl/" score: 6 createdAt: "2019-05-22T13:40:39Z" authorHandle: "f72b7979" isOriginalPoster: false isPostBody: false postTitle: null wordCount: 25 excerpt: "Bromelain, ginger, circumin, and boswellia is a pretty good inflammation stack that's pretty well tolerated. You night give those a try instead of Advil :)"
- sourceThread: "r/longevity" permalink: "https://www.reddit.com/r/longevity/comments/8fcclj/what_are_you_doing_to_extend_your_life/dy2du2z/" score: 6 createdAt: "2018-04-27T15:57:02Z" authorHandle: "247d0aaf" isOriginalPoster: false isPostBody: false postTitle: null wordCount: 127 excerpt: "* Vitamin D3
- (edit: also Vitamin K2)
- Tocomin Suprabio (Vitamin E blend, primarily for the d-gamma-tocotrienol to combo with quercetin)
- Quercetin (combo with tocotrineols for senescent cell clearing)
- Sulforaphane (broccoli seed extract)
- Watercress (DNA repair)
- Tumeric Circumin w/ pepper (anti-inflammatory/anti-oxidant/brain health)
- Resveratrol 200 mg (anti-cancer/anti-oxidant/caloric restrictor)
- Pterostilbene (anti-oxidant, anti-cancer, brain health, longevity)
- Gynostemma (neuroprotective, anti-cancer, anti-oxidant)
- Bromelain (anti-inflammatory)
- Alpha Lipoic Acid (adaptogen)
- Olive Leaf (arterial health, anti-cancer, neuroprotective)
- Ginko Biloba (brain health)
- Grapefruit Pectin (artery health)
- Cod Liver Oil (brain fat)
- C60oo (immortality)
- Muira Puama (bra"
- sourceThread: "r/Nootropics" permalink: "https://www.reddit.com/r/Nootropics/comments/u3l1dm/best_substance_to_increase_blood_flow_in_the_brain/i4s74d1/" score: 5 createdAt: "2022-04-15T02:17:20Z" authorHandle: "09c33016" isOriginalPoster: false isPostBody: false postTitle: null wordCount: 85 excerpt: "This is one of my favorite topics.
Here are two substances with novel mechansims of action (they are not direct vasodilators):
Fibrinolytic drugs. Bromelain or, even better, nattokinase. These substances can improve cerebral microcirculation, especially if you have any chronic inflammation. (If you don't have chronic inflammation, it's sort of unlikely that you need more blood in your brain anyway; too much blood in your brain is not good).
Intranasal insulin also increases cerebral blood flow.
Both of these are some of my absolute favorites."
- sourceThread: "r/Nootropics" permalink: "https://www.reddit.com/r/Nootropics/comments/e87wzw/the_strongest_antiinflammatory_substances/facnmrh/" score: 5 createdAt: "2019-12-10T01:58:25Z" authorHandle: "cab2aea6" isOriginalPoster: false isPostBody: false postTitle: null wordCount: 24 excerpt: "I’ve never found a stronger herbal anti inflammatory than Boswellia, and I’ve tried black cumin, curcumin/turmeric, bromelain, and ginger, and more. Boswellia is king."
- sourceThread: "r/Nootropics" permalink: "https://www.reddit.com/r/Nootropics/comments/e87wzw/the_strongest_antiinflammatory_substances/fabawsk/" score: 5 createdAt: "2019-12-09T19:40:28Z" authorHandle: "b3a9588b" isOriginalPoster: false isPostBody: false postTitle: null wordCount: 430 excerpt: "address the cause first; for me it seems sugar addiction and EGCG for pancreas function was recc'd and i try to have it whenever i have my coffee and pastries.
sometimes a synergistic cocktail might be something to try. It's going to be a long list (of mostly plant alkaloids); here's a small fraction of some because my memory is bad
rutin, bromelaine, berberine ( tiny.cc/2ghghz ), tumeric/ginger (dose carefully), olive leaf
prescription of cannabis?
exercise
avoid selenium deficiency but dose carefully and along with vit e . also avoid less common deficiencies.
and mostly try to get at the root of the cause. you might try switching to all organic especially for grains. there is a glyphosate gout epidemic ongoing; long term abuse of this bioaccumulation often leads to allergies to mis"
- sourceThread: "r/Nootropics" permalink: "https://www.reddit.com/r/Nootropics/comments/bm2xw7/sleep_deprivation_cures_my_adhd_has_anyone/emu9ekr/" score: 5 createdAt: "2019-05-08T16:01:40Z" authorHandle: "f72b7979" isOriginalPoster: false isPostBody: false postTitle: null wordCount: 24 excerpt: "So if that's correct, then maybe Bromelain, White Willow, Boswellia, and Rosemary might help with his adhd symptoms? (All either anti-inflammatory or inflammation suppressing)"
- sourceThread: "r/StackAdvice" permalink: "https://www.reddit.com/r/StackAdvice/comments/z5stog/help_me_long_post/ixy8zga/" score: 5 createdAt: "2022-11-27T08:46:35Z" authorHandle: "3276ac80" isOriginalPoster: false isPostBody: false postTitle: null wordCount: 791 excerpt: "I would need to coach you on how to eat. I am prone to delete it without an upvote.
Let's talk about eating medicinal food that is inexpensive and quick to prepare.
I would like to share with you that sardines are $1/can at the grocery store right now. They are high in vitamin B12, vitamin D, and healthy fish fats. I am thinking of how to share the recipe of Mediterranean Sardines (smashed with a fork) and mayonnaise with whole-wheat saltine crackers to everyone, which is the definition of a social activity that looks out for everyone. Sardines are essential to understand as a fatty fish for $1/serving. They will raise vitamin D levels this winter. If you are like me, you will feel calm, rejuvenated, and awake from the mega-dose of B12 alone.
A distant second meal is baked potato with b"
- sourceThread: "r/StackAdvice" permalink: "https://www.reddit.com/r/StackAdvice/comments/3g2z16/_/ctudlwi" score: 5 createdAt: "2015-08-07T02:42:29Z" authorHandle: "572c0959" isOriginalPoster: false isPostBody: false postTitle: null wordCount: 113 excerpt: "Why are you taking turmeric and not curcumin? Unless you mean curcumin, then that's fine.
Alpha Brain is kinda expensive and the most useful ingredient is probably just bacopa, which can be sourced elsewhere for much less. e.g. swanson bacognize or vitacost bacognize.
ALCAR is unlikely to be very remarkable for focus and recall in healthy people. Benefits are usually remarked in the context of disease such as chronic fatigue and later life decline: http://examine.com/supplements/l-carnitine/ - Harmless enough to trial it yourself though.
Other anti-inflammatory things: Pycnogenol (probably extends to the cheaper pine park), Spirulina, [Cissus](http:"
- sourceThread: "r/Nootropics" permalink: "https://www.reddit.com/r/Nootropics/comments/12u045n/your_top_5_supplements/jh7on30/" score: 4 createdAt: "2023-04-22T00:19:59Z" authorHandle: "c367be0a" isOriginalPoster: false isPostBody: false postTitle: null wordCount: 68 excerpt: "Some uncommon ones I could swap out as my top 5
Trace Mineral Drops—Makes any and all water mineral.
L-Theanine- Focus and calm
Cod lover oil. Bio available and rancid proof forms of epa and dha, plus nice ratios of vitamin a and d
L-Tyrosine. Replenishes dopamine
Bromelain Extract- my current girl I’m dating and every I’ve dated since taking this loves swallowing."
- sourceThread: "r/Nootropics" permalink: "https://www.reddit.com/r/Nootropics/comments/vjnbqc/nootropics_ive_tried_for_brain_fog_ranked_long/idmkynb/" score: 4 createdAt: "2022-06-24T23:55:23Z" authorHandle: "09c33016" isOriginalPoster: false isPostBody: false postTitle: null wordCount: 31 excerpt: "There are better ways to deal with disordered coagulation than probiotics. Fibrinolytics are a class of supplements / drugs. Bromelain and nattokinase are my favorites; piracetam is also one I believe."
- sourceThread: "r/Nootropics" permalink: "https://www.reddit.com/r/Nootropics/comments/rwcajm/nac_helps_anxiety_depression_sleep_apnea_now_covid/hrbyrox/" score: 4 createdAt: "2022-01-05T08:52:16Z" authorHandle: "bd6d6bb2" isOriginalPoster: false isPostBody: false postTitle: null wordCount: 122 excerpt: "This is the exact general / anti-covid stack I've been running for about 1.5 years now. Before that I ran the same sans quercetin/bromelain. Thought, I only use NAC in small cycles or if OURA signals my body might be fighting off something.
I've accidentally been in close proximity or even hugged people that was later hit with covid 5 times that I know of. Most of these have probably been omicron from the last month.
No positive tests yet. I did have flu-like symptoms with slight fever a few days in December though. Was 100% in 3 days.
Before that I hadn't been sick one day in about 7 years. I highly, highly recommend this stack for anyone. Covid or not."
- sourceThread: "r/Nootropics" permalink: "https://www.reddit.com/r/Nootropics/comments/c5wzfp/nootropics_fueled_successlife_change/es6ml2q/" score: 4 createdAt: "2019-06-27T16:24:47Z" authorHandle: "633bef63" isOriginalPoster: false isPostBody: false postTitle: null wordCount: 108 excerpt: "I suffer from depression, anxiety, and OCD. I still take some pharmaceuticals but have been able to drastically lower my doses (I used to be basically a zombie) thanks to intermittent use of phenibut, taurine, and inositol. Those three have helped me succeed at my job whereas before I was really struggling due to the high doses of pharmaceuticals. I also take enzymes with bromelain in them multiple times a day to help with wound healing (the OCD causes me to pick at my own skin), and NAC when I remember.
EDIT: I also take kratom with black coffee a few times a day. That helps with energy." attribution: sources: - name: "dopamine.club" role: "community aggregate stats, dose distribution, stack synergies, AI-seeded interactions" url: "https://dopamine.club/substances/bromelain/" - name: "reddit" role: "paragraph-level community anecdotes" url: "https://reddit.com" text: "Aggregated from creator-curated and community sources. Verify dose, sourcing, and safety before use."
=== community-data-block:end ===
To prevent hypercholesterolemia for cheaper (and likely m"
- sourceThread: "r/Biohackers" permalink: "https://www.reddit.com/r/Biohackers/comments/1jgp8jz/whats_your_go_to_for_oh_no_i_may_be_getting_sick/mj160d2/" score: 11 createdAt: "2025-03-21T20:01:33Z" authorHandle: "08c8d39f" isOriginalPoster: false isPostBody: false postTitle: null wordCount: 56 excerpt: "Never got sick even during Covid!
-Raw garlic cloves in manuka honey
Irwin Naturals Pure Defense Mushroom-8 Immune
Clean Nutraceuticals NAC Supplement N-Acetyl Cysteine Vitamin D3 K2 Zinc Quercetin Sarracenia Purpurea with Elderberry Holy Basil Bee Propolis Bromelain L-Lysine
Propolis Throat Spray by Beekeeper's Naturals - 95% Bee Propolis Extract, Natural Immune Support
- sourceThread: "r/Nootropics" permalink: "https://www.reddit.com/r/Nootropics/comments/rwcajm/nac_helps_anxiety_depression_sleep_apnea_now_covid/hrbbx8r/" score: 10 createdAt: "2022-01-05T04:49:38Z" authorHandle: "5ccaff7b" isOriginalPoster: false isPostBody: false postTitle: null wordCount: 67 excerpt: "I've been doing a fairly regular stack of C, D3, Zinc, Quercetin, Bromelain, NAC, Mg and Melatonin for a few months. I got sick last week for the first time during the pandemic and was at 80% within 24 hours, 100% aside from lingering sniffle within 3 days.
Anecdotal, but definitely seemed to help. I upped the NAC, C and Quercetin doses when I started feeling symptoms."
- sourceThread: "r/Nootropics" permalink: "https://www.reddit.com/r/Nootropics/comments/vjnbqc/nootropics_ive_tried_for_brain_fog_ranked_long/idmmgb3/" score: 9 createdAt: "2022-06-25T00:07:18Z" authorHandle: "09c33016" isOriginalPoster: false isPostBody: false postTitle: null wordCount: 327 excerpt: "I can't believe the lack of public information on this topic. The medical community has given absolutely zero good actionable advice on this topic, demonstrating once again that mainstream medicine makes no basically no attempt to treat chronic illnesses which can't directly be tested for (unlike, e.g. multiple sclerosis). It's a bit criminal.
- Fibrinolytic drugs. Disordered (typically excessive) blood coagulation is a major aspect of long covid. Fibrinolytic drugs dissolve fibrin agglomerations, and commonly other related things like atherosclerotic plaques and amyloid beta deposits. They're amazing supplements, a must-try for long covid. [The cfsremission.com blog is where I learned about this; an incredible resource for all chronic illness sufferers](https://cfsremission.com/tr"
- sourceThread: "r/Nootropics" permalink: "https://www.reddit.com/r/Nootropics/comments/jtn26m/aspirin_for_cellular_respiration_and_youth/gc6rhuf/" score: 9 createdAt: "2020-11-13T20:33:49Z" authorHandle: "4db9b812" isOriginalPoster: false isPostBody: false postTitle: null wordCount: 122 excerpt: "I wonder how much of it was simply aspirin's anti-inflammatory effect, in which case you could try bromelain to avoid the deleterious effects from prolonged COX-1 inhibition.
Taking cortisone for a few days before an MRI made me realize how inflammed I was. Euphoric relief washed over my whole body. I had little idea what cortisone even was, had to look it up and find out it's an anti-inflammatory. Prior, I'd have simply reported feelings of fatigue, low mood, irritability, insomnia, that are always easy to accept as just a slump/phase (and could be explained by my real life situation at the time, lots of stress, dissatisfied, night shifts etc). I was able to find that same kind of relief in bromelain."
- sourceThread: "r/Nootropics" permalink: "https://www.reddit.com/r/Nootropics/comments/mrz9uo/quercetin_impairs_learning_and_memory_in_normal/gupzt0y/" score: 8 createdAt: "2021-04-16T13:26:53Z" authorHandle: "bf8333a2" isOriginalPoster: false isPostBody: false postTitle: null wordCount: 18 excerpt: "Probably bromelain, vitamin C and piperine/bioperine can improve the absorption.
Onion quercetin is better absorbed than apple quercetin"
- sourceThread: "r/StackAdvice" permalink: "https://www.reddit.com/r/StackAdvice/comments/11rkjxi/what_is_your_anti_inflamatory_stack_and_why/jc9pz3p/" score: 8 createdAt: "2023-03-15T08:35:41Z" authorHandle: "45e35081" isOriginalPoster: false isPostBody: false postTitle: null wordCount: 27 excerpt: "Quercetin and bromelain, Vitamin K and D, astaxanthan, fish oil, turmeric, boron, msm, and coq10.
I have osteoarthritis and this combo has been helping with the pain."
- sourceThread: "r/Nootropics" permalink: "https://www.reddit.com/r/Nootropics/comments/106bsnp/going_off_of_my_nootropics_almost_killed_me/j3len62/" score: 6 createdAt: "2023-01-09T10:58:18Z" authorHandle: "395591f8" isOriginalPoster: false isPostBody: false postTitle: null wordCount: 134 excerpt: "I'll second how effective Quercetin is for inhibiting histamine.
I've been using it for 3 months with very good results and, usually, kicks in within 15-20 mins.
I had been searching for something to replace OTC anti-histamine drugs as they make me so drowsy and, basically, unproductive for half to a full day (probably removing too much histamine from the brain but idk).
Quercetin (with Bromelain) really works far better than I was expecting. I found L-theanine comes second to it but takes a little longer to kick in and I'm not certain it's as effective but still worth trying.
I've also read in a study (and I've lost the source now) that Cranberry increases Quercetin absorption (along with Bromelain and something fatty). I've tried them all but can't really vouch for increased effec"
- sourceThread: "r/Nootropics" permalink: "https://www.reddit.com/r/Nootropics/comments/rwcajm/nac_helps_anxiety_depression_sleep_apnea_now_covid/hrce84n/" score: 6 createdAt: "2022-01-05T12:02:05Z" authorHandle: "bd6d6bb2" isOriginalPoster: false isPostBody: false postTitle: null wordCount: 306 excerpt: "Sorry for my early morning gibberish. I'll try again, with some more detail:
I've only been with a few days of fever last month in the last 7 years. However, I forgotten how old I am (and how time flies), it's actually 9.5 years ago I had the flu, strep throat or the cold last.
Base stack (daily):
500mg ascorbyl palmitat (superior form of C-vit) - replaced ascorbic acid after I had developed two lipomas. AP has anti-tumor effects in fatty tissue, which is what lipomas are. One went away by itself, other got removed. None have re-emerged since.
High quality krill oil (1.5g EPA)
30mg zinc (with some cobber)
500mg Magnesium complex
125mcg D3 (with K-complex and iodine)
12mg astaxanthin
B-vit complex (every other day)
Bromelain 300mg / quercetin 1g - added to the stack after a pa"
- sourceThread: "r/Nootropics" permalink: "https://www.reddit.com/r/Nootropics/comments/brn7df/advil_helps_with_my_brain_fog/eofeqwl/" score: 6 createdAt: "2019-05-22T13:40:39Z" authorHandle: "f72b7979" isOriginalPoster: false isPostBody: false postTitle: null wordCount: 25 excerpt: "Bromelain, ginger, circumin, and boswellia is a pretty good inflammation stack that's pretty well tolerated. You night give those a try instead of Advil :)"
- sourceThread: "r/longevity" permalink: "https://www.reddit.com/r/longevity/comments/8fcclj/what_are_you_doing_to_extend_your_life/dy2du2z/" score: 6 createdAt: "2018-04-27T15:57:02Z" authorHandle: "247d0aaf" isOriginalPoster: false isPostBody: false postTitle: null wordCount: 127 excerpt: "* Vitamin D3
- (edit: also Vitamin K2)
- Tocomin Suprabio (Vitamin E blend, primarily for the d-gamma-tocotrienol to combo with quercetin)
- Quercetin (combo with tocotrineols for senescent cell clearing)
- Sulforaphane (broccoli seed extract)
- Watercress (DNA repair)
- Tumeric Circumin w/ pepper (anti-inflammatory/anti-oxidant/brain health)
- Resveratrol 200 mg (anti-cancer/anti-oxidant/caloric restrictor)
- Pterostilbene (anti-oxidant, anti-cancer, brain health, longevity)
- Gynostemma (neuroprotective, anti-cancer, anti-oxidant)
- Bromelain (anti-inflammatory)
- Alpha Lipoic Acid (adaptogen)
- Olive Leaf (arterial health, anti-cancer, neuroprotective)
- Ginko Biloba (brain health)
- Grapefruit Pectin (artery health)
- Cod Liver Oil (brain fat)
- C60oo (immortality)
- Muira Puama (bra"
- sourceThread: "r/Nootropics" permalink: "https://www.reddit.com/r/Nootropics/comments/u3l1dm/best_substance_to_increase_blood_flow_in_the_brain/i4s74d1/" score: 5 createdAt: "2022-04-15T02:17:20Z" authorHandle: "09c33016" isOriginalPoster: false isPostBody: false postTitle: null wordCount: 85 excerpt: "This is one of my favorite topics.
Here are two substances with novel mechansims of action (they are not direct vasodilators):
Fibrinolytic drugs. Bromelain or, even better, nattokinase. These substances can improve cerebral microcirculation, especially if you have any chronic inflammation. (If you don't have chronic inflammation, it's sort of unlikely that you need more blood in your brain anyway; too much blood in your brain is not good).
Intranasal insulin also increases cerebral blood flow.
Both of these are some of my absolute favorites."
- sourceThread: "r/Nootropics" permalink: "https://www.reddit.com/r/Nootropics/comments/e87wzw/the_strongest_antiinflammatory_substances/facnmrh/" score: 5 createdAt: "2019-12-10T01:58:25Z" authorHandle: "cab2aea6" isOriginalPoster: false isPostBody: false postTitle: null wordCount: 24 excerpt: "I’ve never found a stronger herbal anti inflammatory than Boswellia, and I’ve tried black cumin, curcumin/turmeric, bromelain, and ginger, and more. Boswellia is king."
- sourceThread: "r/Nootropics" permalink: "https://www.reddit.com/r/Nootropics/comments/e87wzw/the_strongest_antiinflammatory_substances/fabawsk/" score: 5 createdAt: "2019-12-09T19:40:28Z" authorHandle: "b3a9588b" isOriginalPoster: false isPostBody: false postTitle: null wordCount: 430 excerpt: "address the cause first; for me it seems sugar addiction and EGCG for pancreas function was recc'd and i try to have it whenever i have my coffee and pastries.
sometimes a synergistic cocktail might be something to try. It's going to be a long list (of mostly plant alkaloids); here's a small fraction of some because my memory is bad
rutin, bromelaine, berberine ( tiny.cc/2ghghz ), tumeric/ginger (dose carefully), olive leaf
prescription of cannabis?
exercise
avoid selenium deficiency but dose carefully and along with vit e . also avoid less common deficiencies.
and mostly try to get at the root of the cause. you might try switching to all organic especially for grains. there is a glyphosate gout epidemic ongoing; long term abuse of this bioaccumulation often leads to allergies to mis"
- sourceThread: "r/Nootropics" permalink: "https://www.reddit.com/r/Nootropics/comments/bm2xw7/sleep_deprivation_cures_my_adhd_has_anyone/emu9ekr/" score: 5 createdAt: "2019-05-08T16:01:40Z" authorHandle: "f72b7979" isOriginalPoster: false isPostBody: false postTitle: null wordCount: 24 excerpt: "So if that's correct, then maybe Bromelain, White Willow, Boswellia, and Rosemary might help with his adhd symptoms? (All either anti-inflammatory or inflammation suppressing)"
- sourceThread: "r/StackAdvice" permalink: "https://www.reddit.com/r/StackAdvice/comments/z5stog/help_me_long_post/ixy8zga/" score: 5 createdAt: "2022-11-27T08:46:35Z" authorHandle: "3276ac80" isOriginalPoster: false isPostBody: false postTitle: null wordCount: 791 excerpt: "I would need to coach you on how to eat. I am prone to delete it without an upvote.
Let's talk about eating medicinal food that is inexpensive and quick to prepare.
I would like to share with you that sardines are $1/can at the grocery store right now. They are high in vitamin B12, vitamin D, and healthy fish fats. I am thinking of how to share the recipe of Mediterranean Sardines (smashed with a fork) and mayonnaise with whole-wheat saltine crackers to everyone, which is the definition of a social activity that looks out for everyone. Sardines are essential to understand as a fatty fish for $1/serving. They will raise vitamin D levels this winter. If you are like me, you will feel calm, rejuvenated, and awake from the mega-dose of B12 alone.
A distant second meal is baked potato with b"
- sourceThread: "r/StackAdvice" permalink: "https://www.reddit.com/r/StackAdvice/comments/3g2z16/_/ctudlwi" score: 5 createdAt: "2015-08-07T02:42:29Z" authorHandle: "572c0959" isOriginalPoster: false isPostBody: false postTitle: null wordCount: 113 excerpt: "Why are you taking turmeric and not curcumin? Unless you mean curcumin, then that's fine.
Alpha Brain is kinda expensive and the most useful ingredient is probably just bacopa, which can be sourced elsewhere for much less. e.g. swanson bacognize or vitacost bacognize.
ALCAR is unlikely to be very remarkable for focus and recall in healthy people. Benefits are usually remarked in the context of disease such as chronic fatigue and later life decline: http://examine.com/supplements/l-carnitine/ - Harmless enough to trial it yourself though.
Other anti-inflammatory things: Pycnogenol (probably extends to the cheaper pine park), Spirulina, [Cissus](http:"
- sourceThread: "r/Nootropics" permalink: "https://www.reddit.com/r/Nootropics/comments/12u045n/your_top_5_supplements/jh7on30/" score: 4 createdAt: "2023-04-22T00:19:59Z" authorHandle: "c367be0a" isOriginalPoster: false isPostBody: false postTitle: null wordCount: 68 excerpt: "Some uncommon ones I could swap out as my top 5
Trace Mineral Drops—Makes any and all water mineral.
L-Theanine- Focus and calm
Cod lover oil. Bio available and rancid proof forms of epa and dha, plus nice ratios of vitamin a and d
L-Tyrosine. Replenishes dopamine
Bromelain Extract- my current girl I’m dating and every I’ve dated since taking this loves swallowing."
- sourceThread: "r/Nootropics" permalink: "https://www.reddit.com/r/Nootropics/comments/vjnbqc/nootropics_ive_tried_for_brain_fog_ranked_long/idmkynb/" score: 4 createdAt: "2022-06-24T23:55:23Z" authorHandle: "09c33016" isOriginalPoster: false isPostBody: false postTitle: null wordCount: 31 excerpt: "There are better ways to deal with disordered coagulation than probiotics. Fibrinolytics are a class of supplements / drugs. Bromelain and nattokinase are my favorites; piracetam is also one I believe."
- sourceThread: "r/Nootropics" permalink: "https://www.reddit.com/r/Nootropics/comments/rwcajm/nac_helps_anxiety_depression_sleep_apnea_now_covid/hrbyrox/" score: 4 createdAt: "2022-01-05T08:52:16Z" authorHandle: "bd6d6bb2" isOriginalPoster: false isPostBody: false postTitle: null wordCount: 122 excerpt: "This is the exact general / anti-covid stack I've been running for about 1.5 years now. Before that I ran the same sans quercetin/bromelain. Thought, I only use NAC in small cycles or if OURA signals my body might be fighting off something.
I've accidentally been in close proximity or even hugged people that was later hit with covid 5 times that I know of. Most of these have probably been omicron from the last month.
No positive tests yet. I did have flu-like symptoms with slight fever a few days in December though. Was 100% in 3 days.
Before that I hadn't been sick one day in about 7 years. I highly, highly recommend this stack for anyone. Covid or not."
- sourceThread: "r/Nootropics" permalink: "https://www.reddit.com/r/Nootropics/comments/c5wzfp/nootropics_fueled_successlife_change/es6ml2q/" score: 4 createdAt: "2019-06-27T16:24:47Z" authorHandle: "633bef63" isOriginalPoster: false isPostBody: false postTitle: null wordCount: 108 excerpt: "I suffer from depression, anxiety, and OCD. I still take some pharmaceuticals but have been able to drastically lower my doses (I used to be basically a zombie) thanks to intermittent use of phenibut, taurine, and inositol. Those three have helped me succeed at my job whereas before I was really struggling due to the high doses of pharmaceuticals. I also take enzymes with bromelain in them multiple times a day to help with wound healing (the OCD causes me to pick at my own skin), and NAC when I remember.
EDIT: I also take kratom with black coffee a few times a day. That helps with energy." attribution: sources: - name: "dopamine.club" role: "community aggregate stats, dose distribution, stack synergies, AI-seeded interactions" url: "https://dopamine.club/substances/bromelain/" - name: "reddit" role: "paragraph-level community anecdotes" url: "https://reddit.com" text: "Aggregated from creator-curated and community sources. Verify dose, sourcing, and safety before use."
=== community-data-block:end ===
To prevent hypercholesterolemia for cheaper (and likely m"
- sourceThread: "r/Biohackers" permalink: "https://www.reddit.com/r/Biohackers/comments/1jgp8jz/whats_your_go_to_for_oh_no_i_may_be_getting_sick/mj160d2/" score: 11 createdAt: "2025-03-21T20:01:33Z" authorHandle: "08c8d39f" isOriginalPoster: false isPostBody: false postTitle: null wordCount: 56 excerpt: "Never got sick even during Covid!
-Raw garlic cloves in manuka honey
Irwin Naturals Pure Defense Mushroom-8 Immune
Clean Nutraceuticals NAC Supplement N-Acetyl Cysteine Vitamin D3 K2 Zinc Quercetin Sarracenia Purpurea with Elderberry Holy Basil Bee Propolis Bromelain L-Lysine
Propolis Throat Spray by Beekeeper's Naturals - 95% Bee Propolis Extract, Natural Immune Support
- sourceThread: "r/Nootropics" permalink: "https://www.reddit.com/r/Nootropics/comments/rwcajm/nac_helps_anxiety_depression_sleep_apnea_now_covid/hrbbx8r/" score: 10 createdAt: "2022-01-05T04:49:38Z" authorHandle: "5ccaff7b" isOriginalPoster: false isPostBody: false postTitle: null wordCount: 67 excerpt: "I've been doing a fairly regular stack of C, D3, Zinc, Quercetin, Bromelain, NAC, Mg and Melatonin for a few months. I got sick last week for the first time during the pandemic and was at 80% within 24 hours, 100% aside from lingering sniffle within 3 days.
Anecdotal, but definitely seemed to help. I upped the NAC, C and Quercetin doses when I started feeling symptoms."
- sourceThread: "r/Nootropics" permalink: "https://www.reddit.com/r/Nootropics/comments/vjnbqc/nootropics_ive_tried_for_brain_fog_ranked_long/idmmgb3/" score: 9 createdAt: "2022-06-25T00:07:18Z" authorHandle: "09c33016" isOriginalPoster: false isPostBody: false postTitle: null wordCount: 327 excerpt: "I can't believe the lack of public information on this topic. The medical community has given absolutely zero good actionable advice on this topic, demonstrating once again that mainstream medicine makes no basically no attempt to treat chronic illnesses which can't directly be tested for (unlike, e.g. multiple sclerosis). It's a bit criminal.
- Fibrinolytic drugs. Disordered (typically excessive) blood coagulation is a major aspect of long covid. Fibrinolytic drugs dissolve fibrin agglomerations, and commonly other related things like atherosclerotic plaques and amyloid beta deposits. They're amazing supplements, a must-try for long covid. [The cfsremission.com blog is where I learned about this; an incredible resource for all chronic illness sufferers](https://cfsremission.com/tr"
- sourceThread: "r/Nootropics" permalink: "https://www.reddit.com/r/Nootropics/comments/jtn26m/aspirin_for_cellular_respiration_and_youth/gc6rhuf/" score: 9 createdAt: "2020-11-13T20:33:49Z" authorHandle: "4db9b812" isOriginalPoster: false isPostBody: false postTitle: null wordCount: 122 excerpt: "I wonder how much of it was simply aspirin's anti-inflammatory effect, in which case you could try bromelain to avoid the deleterious effects from prolonged COX-1 inhibition.
Taking cortisone for a few days before an MRI made me realize how inflammed I was. Euphoric relief washed over my whole body. I had little idea what cortisone even was, had to look it up and find out it's an anti-inflammatory. Prior, I'd have simply reported feelings of fatigue, low mood, irritability, insomnia, that are always easy to accept as just a slump/phase (and could be explained by my real life situation at the time, lots of stress, dissatisfied, night shifts etc). I was able to find that same kind of relief in bromelain."
- sourceThread: "r/Nootropics" permalink: "https://www.reddit.com/r/Nootropics/comments/mrz9uo/quercetin_impairs_learning_and_memory_in_normal/gupzt0y/" score: 8 createdAt: "2021-04-16T13:26:53Z" authorHandle: "bf8333a2" isOriginalPoster: false isPostBody: false postTitle: null wordCount: 18 excerpt: "Probably bromelain, vitamin C and piperine/bioperine can improve the absorption.
Onion quercetin is better absorbed than apple quercetin"
- sourceThread: "r/StackAdvice" permalink: "https://www.reddit.com/r/StackAdvice/comments/11rkjxi/what_is_your_anti_inflamatory_stack_and_why/jc9pz3p/" score: 8 createdAt: "2023-03-15T08:35:41Z" authorHandle: "45e35081" isOriginalPoster: false isPostBody: false postTitle: null wordCount: 27 excerpt: "Quercetin and bromelain, Vitamin K and D, astaxanthan, fish oil, turmeric, boron, msm, and coq10.
I have osteoarthritis and this combo has been helping with the pain."
- sourceThread: "r/Nootropics" permalink: "https://www.reddit.com/r/Nootropics/comments/106bsnp/going_off_of_my_nootropics_almost_killed_me/j3len62/" score: 6 createdAt: "2023-01-09T10:58:18Z" authorHandle: "395591f8" isOriginalPoster: false isPostBody: false postTitle: null wordCount: 134 excerpt: "I'll second how effective Quercetin is for inhibiting histamine.
I've been using it for 3 months with very good results and, usually, kicks in within 15-20 mins.
I had been searching for something to replace OTC anti-histamine drugs as they make me so drowsy and, basically, unproductive for half to a full day (probably removing too much histamine from the brain but idk).
Quercetin (with Bromelain) really works far better than I was expecting. I found L-theanine comes second to it but takes a little longer to kick in and I'm not certain it's as effective but still worth trying.
I've also read in a study (and I've lost the source now) that Cranberry increases Quercetin absorption (along with Bromelain and something fatty). I've tried them all but can't really vouch for increased effec"
- sourceThread: "r/Nootropics" permalink: "https://www.reddit.com/r/Nootropics/comments/rwcajm/nac_helps_anxiety_depression_sleep_apnea_now_covid/hrce84n/" score: 6 createdAt: "2022-01-05T12:02:05Z" authorHandle: "bd6d6bb2" isOriginalPoster: false isPostBody: false postTitle: null wordCount: 306 excerpt: "Sorry for my early morning gibberish. I'll try again, with some more detail:
I've only been with a few days of fever last month in the last 7 years. However, I forgotten how old I am (and how time flies), it's actually 9.5 years ago I had the flu, strep throat or the cold last.
Base stack (daily):
500mg ascorbyl palmitat (superior form of C-vit) - replaced ascorbic acid after I had developed two lipomas. AP has anti-tumor effects in fatty tissue, which is what lipomas are. One went away by itself, other got removed. None have re-emerged since.
High quality krill oil (1.5g EPA)
30mg zinc (with some cobber)
500mg Magnesium complex
125mcg D3 (with K-complex and iodine)
12mg astaxanthin
B-vit complex (every other day)
Bromelain 300mg / quercetin 1g - added to the stack after a pa"
- sourceThread: "r/Nootropics" permalink: "https://www.reddit.com/r/Nootropics/comments/brn7df/advil_helps_with_my_brain_fog/eofeqwl/" score: 6 createdAt: "2019-05-22T13:40:39Z" authorHandle: "f72b7979" isOriginalPoster: false isPostBody: false postTitle: null wordCount: 25 excerpt: "Bromelain, ginger, circumin, and boswellia is a pretty good inflammation stack that's pretty well tolerated. You night give those a try instead of Advil :)"
- sourceThread: "r/longevity" permalink: "https://www.reddit.com/r/longevity/comments/8fcclj/what_are_you_doing_to_extend_your_life/dy2du2z/" score: 6 createdAt: "2018-04-27T15:57:02Z" authorHandle: "247d0aaf" isOriginalPoster: false isPostBody: false postTitle: null wordCount: 127 excerpt: "* Vitamin D3
- (edit: also Vitamin K2)
- Tocomin Suprabio (Vitamin E blend, primarily for the d-gamma-tocotrienol to combo with quercetin)
- Quercetin (combo with tocotrineols for senescent cell clearing)
- Sulforaphane (broccoli seed extract)
- Watercress (DNA repair)
- Tumeric Circumin w/ pepper (anti-inflammatory/anti-oxidant/brain health)
- Resveratrol 200 mg (anti-cancer/anti-oxidant/caloric restrictor)
- Pterostilbene (anti-oxidant, anti-cancer, brain health, longevity)
- Gynostemma (neuroprotective, anti-cancer, anti-oxidant)
- Bromelain (anti-inflammatory)
- Alpha Lipoic Acid (adaptogen)
- Olive Leaf (arterial health, anti-cancer, neuroprotective)
- Ginko Biloba (brain health)
- Grapefruit Pectin (artery health)
- Cod Liver Oil (brain fat)
- C60oo (immortality)
- Muira Puama (bra"
- sourceThread: "r/Nootropics" permalink: "https://www.reddit.com/r/Nootropics/comments/u3l1dm/best_substance_to_increase_blood_flow_in_the_brain/i4s74d1/" score: 5 createdAt: "2022-04-15T02:17:20Z" authorHandle: "09c33016" isOriginalPoster: false isPostBody: false postTitle: null wordCount: 85 excerpt: "This is one of my favorite topics.
Here are two substances with novel mechansims of action (they are not direct vasodilators):
Fibrinolytic drugs. Bromelain or, even better, nattokinase. These substances can improve cerebral microcirculation, especially if you have any chronic inflammation. (If you don't have chronic inflammation, it's sort of unlikely that you need more blood in your brain anyway; too much blood in your brain is not good).
Intranasal insulin also increases cerebral blood flow.
Both of these are some of my absolute favorites."
- sourceThread: "r/Nootropics" permalink: "https://www.reddit.com/r/Nootropics/comments/e87wzw/the_strongest_antiinflammatory_substances/facnmrh/" score: 5 createdAt: "2019-12-10T01:58:25Z" authorHandle: "cab2aea6" isOriginalPoster: false isPostBody: false postTitle: null wordCount: 24 excerpt: "I’ve never found a stronger herbal anti inflammatory than Boswellia, and I’ve tried black cumin, curcumin/turmeric, bromelain, and ginger, and more. Boswellia is king."
- sourceThread: "r/Nootropics" permalink: "https://www.reddit.com/r/Nootropics/comments/e87wzw/the_strongest_antiinflammatory_substances/fabawsk/" score: 5 createdAt: "2019-12-09T19:40:28Z" authorHandle: "b3a9588b" isOriginalPoster: false isPostBody: false postTitle: null wordCount: 430 excerpt: "address the cause first; for me it seems sugar addiction and EGCG for pancreas function was recc'd and i try to have it whenever i have my coffee and pastries.
sometimes a synergistic cocktail might be something to try. It's going to be a long list (of mostly plant alkaloids); here's a small fraction of some because my memory is bad
rutin, bromelaine, berberine ( tiny.cc/2ghghz ), tumeric/ginger (dose carefully), olive leaf
prescription of cannabis?
exercise
avoid selenium deficiency but dose carefully and along with vit e . also avoid less common deficiencies.
and mostly try to get at the root of the cause. you might try switching to all organic especially for grains. there is a glyphosate gout epidemic ongoing; long term abuse of this bioaccumulation often leads to allergies to mis"
- sourceThread: "r/Nootropics" permalink: "https://www.reddit.com/r/Nootropics/comments/bm2xw7/sleep_deprivation_cures_my_adhd_has_anyone/emu9ekr/" score: 5 createdAt: "2019-05-08T16:01:40Z" authorHandle: "f72b7979" isOriginalPoster: false isPostBody: false postTitle: null wordCount: 24 excerpt: "So if that's correct, then maybe Bromelain, White Willow, Boswellia, and Rosemary might help with his adhd symptoms? (All either anti-inflammatory or inflammation suppressing)"
- sourceThread: "r/StackAdvice" permalink: "https://www.reddit.com/r/StackAdvice/comments/z5stog/help_me_long_post/ixy8zga/" score: 5 createdAt: "2022-11-27T08:46:35Z" authorHandle: "3276ac80" isOriginalPoster: false isPostBody: false postTitle: null wordCount: 791 excerpt: "I would need to coach you on how to eat. I am prone to delete it without an upvote.
Let's talk about eating medicinal food that is inexpensive and quick to prepare.
I would like to share with you that sardines are $1/can at the grocery store right now. They are high in vitamin B12, vitamin D, and healthy fish fats. I am thinking of how to share the recipe of Mediterranean Sardines (smashed with a fork) and mayonnaise with whole-wheat saltine crackers to everyone, which is the definition of a social activity that looks out for everyone. Sardines are essential to understand as a fatty fish for $1/serving. They will raise vitamin D levels this winter. If you are like me, you will feel calm, rejuvenated, and awake from the mega-dose of B12 alone.
A distant second meal is baked potato with b"
- sourceThread: "r/StackAdvice" permalink: "https://www.reddit.com/r/StackAdvice/comments/3g2z16/_/ctudlwi" score: 5 createdAt: "2015-08-07T02:42:29Z" authorHandle: "572c0959" isOriginalPoster: false isPostBody: false postTitle: null wordCount: 113 excerpt: "Why are you taking turmeric and not curcumin? Unless you mean curcumin, then that's fine.
Alpha Brain is kinda expensive and the most useful ingredient is probably just bacopa, which can be sourced elsewhere for much less. e.g. swanson bacognize or vitacost bacognize.
ALCAR is unlikely to be very remarkable for focus and recall in healthy people. Benefits are usually remarked in the context of disease such as chronic fatigue and later life decline: http://examine.com/supplements/l-carnitine/ - Harmless enough to trial it yourself though.
Other anti-inflammatory things: Pycnogenol (probably extends to the cheaper pine park), Spirulina, [Cissus](http:"
- sourceThread: "r/Nootropics" permalink: "https://www.reddit.com/r/Nootropics/comments/12u045n/your_top_5_supplements/jh7on30/" score: 4 createdAt: "2023-04-22T00:19:59Z" authorHandle: "c367be0a" isOriginalPoster: false isPostBody: false postTitle: null wordCount: 68 excerpt: "Some uncommon ones I could swap out as my top 5
Trace Mineral Drops—Makes any and all water mineral.
L-Theanine- Focus and calm
Cod lover oil. Bio available and rancid proof forms of epa and dha, plus nice ratios of vitamin a and d
L-Tyrosine. Replenishes dopamine
Bromelain Extract- my current girl I’m dating and every I’ve dated since taking this loves swallowing."
- sourceThread: "r/Nootropics" permalink: "https://www.reddit.com/r/Nootropics/comments/vjnbqc/nootropics_ive_tried_for_brain_fog_ranked_long/idmkynb/" score: 4 createdAt: "2022-06-24T23:55:23Z" authorHandle: "09c33016" isOriginalPoster: false isPostBody: false postTitle: null wordCount: 31 excerpt: "There are better ways to deal with disordered coagulation than probiotics. Fibrinolytics are a class of supplements / drugs. Bromelain and nattokinase are my favorites; piracetam is also one I believe."
- sourceThread: "r/Nootropics" permalink: "https://www.reddit.com/r/Nootropics/comments/rwcajm/nac_helps_anxiety_depression_sleep_apnea_now_covid/hrbyrox/" score: 4 createdAt: "2022-01-05T08:52:16Z" authorHandle: "bd6d6bb2" isOriginalPoster: false isPostBody: false postTitle: null wordCount: 122 excerpt: "This is the exact general / anti-covid stack I've been running for about 1.5 years now. Before that I ran the same sans quercetin/bromelain. Thought, I only use NAC in small cycles or if OURA signals my body might be fighting off something.
I've accidentally been in close proximity or even hugged people that was later hit with covid 5 times that I know of. Most of these have probably been omicron from the last month.
No positive tests yet. I did have flu-like symptoms with slight fever a few days in December though. Was 100% in 3 days.
Before that I hadn't been sick one day in about 7 years. I highly, highly recommend this stack for anyone. Covid or not."
- sourceThread: "r/Nootropics" permalink: "https://www.reddit.com/r/Nootropics/comments/c5wzfp/nootropics_fueled_successlife_change/es6ml2q/" score: 4 createdAt: "2019-06-27T16:24:47Z" authorHandle: "633bef63" isOriginalPoster: false isPostBody: false postTitle: null wordCount: 108 excerpt: "I suffer from depression, anxiety, and OCD. I still take some pharmaceuticals but have been able to drastically lower my doses (I used to be basically a zombie) thanks to intermittent use of phenibut, taurine, and inositol. Those three have helped me succeed at my job whereas before I was really struggling due to the high doses of pharmaceuticals. I also take enzymes with bromelain in them multiple times a day to help with wound healing (the OCD causes me to pick at my own skin), and NAC when I remember.
EDIT: I also take kratom with black coffee a few times a day. That helps with energy." attribution: sources: - name: "dopamine.club" role: "community aggregate stats, dose distribution, stack synergies, AI-seeded interactions" url: "https://dopamine.club/substances/bromelain/" - name: "reddit" role: "paragraph-level community anecdotes" url: "https://reddit.com" text: "Aggregated from creator-curated and community sources. Verify dose, sourcing, and safety before use."
=== community-data-block:end ===
Peptide Interactions
Most-combined-with at 85 community mentions. Mechanism: (a) mutual absorption enhancement — community data and mechanistic studies suggest bromelain improves…
Independent anti-inflammatory mechanisms (curcumin: NF-κB + COX-2 + JAK/STAT; bromelain: bradykinin + cytokine + fibrin). Effects appear additive in post-sur…
Omega-3 provides chronic-baseline anti-inflammatory + resolvin-mediated resolution; bromelain provides acute-event proteolytic action. Mechanistically comple…
Multi-pathway anti-inflammatory stack popular in OA. Mechanistically additive (boswellia hits 5-LOX → leukotrienes; bromelain hits NF-κB + bradykinin).
The systemic-enzyme therapy combination — EU-popular, with supportive evidence in OA, TMJ-OA, and post-surgical edema (Bhandari 2024 systematic review).
warfarin, DOACs (apixaban, rivaroxaban, dabigatran, edoxaban), heparin, fondaparinux — additive bleeding risk. Theoretical, not always observed clinically, b…
aspirin (low-dose cardioprotective or higher), clopidogrel, ticagrelor, prasugrel — additive bleeding risk.
additive GI + bleeding risk. Low-dose / occasional NSAID use overlaps acceptably for most users, but chronic high-dose NSAID + bromelain is unwise.
nattokinase, serrapeptase, high-dose fish oil (>3 g/day with anticoagulant), high-dose vitamin E (>800 IU/day), garlic extract — additive bleeding tendency.
(2 weeks each side): discontinue.
What to Expect
- Week 1Tolerability and dose-response.
- Week 2-4Early effect window.
- Week 4-8Peak benefit assessment.
- Week 8+Cycle decision point.
Side Effects & Safety
- Common (>5% of users):
- Mild GI upset (loose stool, mild nausea) — usually transient
- Mild fatigue (community reports — possibly placebo or coincident)
- Less common (1–5%):
- Mild menstrual changes (theoretical mechanism: anticoagulant + uterotonic activity)
- Headache, mild dizziness
- Mild palpitations (rare)
- Rare-serious (<1% but mechanistically real):
- Pineapple / latex / birch-pollen allergic reaction. Cross-reactivity is well-documented. Anyone with pineapple allergy or latex-fruit syndrome should not take bromelain. Presentation: orofacial swelling, urticaria, occasional bronchospasm. Anaphylaxis is rare but reported.
- Bleeding-tendency amplification. In-vitro thromboelastography shows PT/aPTT prolongation and platelet aggregation inhibition (PMID 25517253). Clinical translation is small in healthy users but real in users on anticoagulants. Note: one perioperative study (PMID 21611915) found no enhanced bleeding with concomitant LMWH; the signal varies by clinical setting and concomitant drugs.
- Transaminase elevations — rare, case-reported with very-high-dose chronic use (>3 g/day for months). Reverses on discontinuation.
- Specific watch periods:
- First 30–90 minutes of first dose: Allergic reaction is overwhelmingly first-or-second-dose phenomenon. Stop immediately if any orofacial swelling, hives, or shortness of breath.
- Day 3–7 of a daily course: GI side effects, if they appear, usually emerge here. Reducing per-dose or shifting to BID instead of TID typically resolves.
- 2 weeks pre-elective surgery: Discontinue. This is the formal recommendation across surgical specialties, despite weak direct clinical evidence of bleeding harm — the precautionary principle applies.
Pregnancy / breastfeeding: Avoid. Theoretical concerns include uterine activity + mild anticoagulation. Clinical data are sparse, and the precautionary stance is universal across regulatory sources.
Pediatric use: Used in clinical trials (Braun 2005 in children with sinusitis — well tolerated at age-adjusted doses); NexoBrid pediatric approval Aug 2024. For non-prescribed supplemental use in <16-year-olds, defer to clinician.
References
Leelakanok N et al. Efficacy and safety of bromelain: A systematic review and meta-analysis. Nutr Health 2023;29(3):479-503 (PMID 37157782)
primary 2023 meta-analysis, 39 RCTs
View StudyBrien S et al. Bromelain as a treatment for osteoarthritis: a review of clinical studies. Evid Based Complement Alternat Med 2004 (PMID 15841258)
foundational OA review
View StudyHossain MS et al. Bromelain as a natural anti-inflammatory drug: a systematic review. Naunyn Schmiedebergs Arch Pharmacol 2024 (PMID 38676413)
recent mechanism-focused systematic review
View StudyBhandari R et al. Anti-inflammatory Role of Trypsin, Rutoside, and Bromelain Combination in TMJ Osteoarthritis: A Systematic Review. Cureus 2024 (PMID 38322061)
systemic enzyme combination evidence
View StudyLoo WTY et al. Bromelain-based enzymatic burn debridement: A systematic review. Int Wound J 2024 (PMID 37455553)
NexoBrid post-approval systematic review
View StudyRosenberg L et al. A novel rapid and selective enzymatic debridement agent for burn wound management: a multi-center RCT. Burns 2014 (PMID 24698364)
ESCHAROS trial, basis for NexoBrid FDA approval
View StudyMaurer HR. Bromelain: biochemistry, pharmacology and medical use. Cell Mol Life Sci 2001 (PMID 11497239)
foundational pharmacology review
View StudyPavan R et al. Properties and Therapeutic Application of Bromelain: A Review. Biotechnol Res Int 2012 (PMID 23304525)
widely cited 2012 umbrella review
View StudyCastell JV et al. Intestinal absorption of undegraded proteins in men: presence of bromelain in plasma after oral intake. Am J Physiol 1997 (PMID 9038932)
key oral-bioavailability paper
View StudyAsmara AP et al. Exploring the Therapeutic Potential of Bromelain. Nutrients 2024;16(13):2060 (PMC11243481)
recent comprehensive umbrella review
View StudyHikisz P, Bernasinska-Slomczewska J. Beneficial Properties of Bromelain. Nutrients 2021 (PMID 34067064 mechanistic companion)
NF-κB / MAPK mechanism paper
View StudyBraun JM et al. Therapeutic use, efficiency and safety of Bromelain-POS in children with acute sinusitis. In Vivo 2005 (PMID 15796206)
pediatric sinusitis RCT
View StudyGuo R, Canter PH, Ernst E. Herbal medicines for the treatment of rhinosinusitis: a systematic review. Otolaryngol Head Neck Surg 2006 (PMID 17011407)
sinusitis systematic review
View StudyStone MB et al. Preliminary comparison of bromelain and ibuprofen for delayed onset muscle soreness management. Clin J Sport Med 2002 (PMID 12466693)
counterweight DOMS-null RCT
View StudyShing CM et al. Acute protease supplementation effects on muscle damage and recovery across consecutive days of cycle racing. Eur J Sport Sci 2016 (PMID 25604346)
multi-day protease/bromelain supplementation in endurance athletes
View StudyWalker AF et al. Bromelain reduces mild acute knee pain. Phytomedicine 2002 (PMID 12568257 companion)
knee pain pilot
View StudyBromelain has paradoxical effects on blood coagulability: a study using thromboelastography (PMID 25517253)
coagulation effect characterization
View StudyNo clinical evidence for an enhanced bleeding tendency due to perioperative treatment with bromelain (PMID 21611915)
counterweight on perioperative bleeding risk
View StudyFDA: NexoBrid Prescribing Information (2022/2024 approvals)
regulatory citation
View StudyNCCIH: Bromelain — Usefulness and Safety
regulatory / consumer-facing summary
View StudyHow was your experience with this compound?
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