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Carnosine

needs-research

Aliases (1)
CARNOSINE
TYPICAL DOSE
—
ROUTE
—
CYCLE
—
STORAGE
—

Overview

What is Carnosine?

gently petering out to 8 hours.

Zynamite 300mg, Theacrine 300mg, Caffeine 50mg, GS15-4 100mg, Alpha-GPC 300mg, CDP-Choline 150mg, ALCAR 1g, Magnesium (ATA-Mg is worth the money IMO but L-theronate is very good, I'm also very impressed with bio-optimisers blend of 7. Doses will vary but tend to the high to very high,. Rhodiola Rosea (preferably in 5-2 but 3-1 is fine) in 250-500mg. B-vitamin stack (again doses vary, worth adding in modified b-vitamins IMO, sulbutiamine, emoxypine, benfotiamine). NALT 500mg, DL-Phenylaline 250mg, L-Phenylaline 250mg, EnXtra 300mg, Primavie 200mg, L-Tryptophan 300mg, Trans-Reservatrol 250mg, NMN 500mg, L-theanine 400mg. I could go on, but this is a good example; some of these you might want to tak"

  • sourceThread: "r/StackAdvice" permalink: "https://www.reddit.com/r/StackAdvice/comments/i5kw8p/too_many_stimulants/g0ptr8z/" score: 9 createdAt: "2020-08-07T20:08:59Z" authorHandle: "c633dad2" isOriginalPoster: false isPostBody: false postTitle: null wordCount: 33 excerpt: "Uh u should definitely be on a basic cardioprotective stack with creatine/lysine/carnosine/TAURINE as a amino acid base and NMN/CoQ10/Omega3's/Berberine. Make sure you get enough potassium as well. really surprised you dont use taurine"

  • sourceThread: "r/longevity" permalink: "https://www.reddit.com/r/longevity/comments/7djbcs/the_results_of_most_potential_biomarkers_of_aging/dpzibkw/" score: 8 createdAt: "2017-11-18T01:23:28Z" authorHandle: "03cb838f" isOriginalPoster: false isPostBody: false postTitle: null wordCount: 86 excerpt: "Not surprising, really. Aging is a complex thing. My first telomere test showed that I had the length of a 90 year old. Well I am certainly far from being 90. So using that marker alone as an indication of age would be inaccurate. Scary as hell, though. After a single cycle of Epitalon, Thymalin, GHK-Cu, and L-carnosine, my results showed the length of a 26 year old. My age didn't change, but the marker did. I think environmental factors affect all these markers a lot."

  • sourceThread: "r/Nootropics" permalink: "https://www.reddit.com/r/Nootropics/comments/vop8nk/reliable_source_of_oxytocin_in_the_uk/iefeywf/" score: 7 createdAt: "2022-07-01T08:17:16Z" authorHandle: "6b37059e" isOriginalPoster: false isPostBody: false postTitle: null wordCount: 26 excerpt: "A lot of other supplements can increase oxytocin. 5-HT2A and 5-HT1A agonist can increase oxytocin. Some on top of my mind are l-carnosine, oleoethylamide, yokukansan, psychedelic"

  • sourceThread: "r/Nootropics" permalink: "https://www.reddit.com/r/Nootropics/comments/vgazjt/minerals_neurological_functions/id1y29i/" score: 7 createdAt: "2022-06-20T12:49:55Z" authorHandle: "7321faa3" isOriginalPoster: false isPostBody: false postTitle: null wordCount: 230 excerpt: "Get more:

  • Zinc (Zinc-Carnosine is the best form)

  • Heme-Iron (I use the brand Proferrin, once every 2-3 days)

  • Copper Glycinate (Once every 2 days)

  • Magnesium Threonate or Magnesium Glycinate (1-3x a day or as needed)

  • Lycopene (Can get it from the drink V8, 2-3x a day)

You should also get more antioxidants, plenty of vitamin C but maybe try an NAC supplement too. Glutamate is a co-factor for glutathione synthesis, a powerful antioxidant, and NAC basically lowers glutamate levels by converting it into glutathione... It can help a lot.

Pair the NAC with magnesium glycinate and/or glycine, and vitamin c to make sure it's most effective.

Get more flavonoids and polyphenols, like quercetin, multiple times a day. Home-brewed coffee, tea, and dark chocolate are the best sources"

Dopamine beta-hydroxylase is responsible for the conversion of dopamine to norepinephrine

In theory this would lead to more available dopamine and could lower symptoms of physical anxiety with less norepinephrine

Beta alanine is the rate limiter between the two in carnosine production

I'm 95% sure what I just said is completely true, but all from memory, so do your own fact check

TLDR- beta alanine could increase dopamine and lower norepinephrine

Get sustained release beta alanine, I believe it's called Carnosyn, to avoid an itchy butthole (never experienced it myself, just saying)"

  • sourceThread: "r/StackAdvice" permalink: "https://www.reddit.com/r/StackAdvice/comments/ydpo1p/nootropics_for_combating_sleep_deprivation/itukj4c/" score: 7 createdAt: "2022-10-26T12:48:04Z" authorHandle: "efa21d92" isOriginalPoster: false isPostBody: false postTitle: null wordCount: 140 excerpt: "Modafinil and variants downregulate emotional affect though, which may not be desired when bonding with a newborn. Might be possible to ameliorate by supplementing with oxytocin, but as yet unaware of any research to support this speculation.

Other than that, take from me... you get used to the sleep deprivation after a while and working out care schedule shifts with your partner help a great deal. Inviting grandma to take over for a few nights would also go down well with everyone involved if that's an option for you.

Why no NAC + vitamin C and alpha lipoic acid? Carnosine + aspirin can be quite helpful for neuroinflammation tiredness too, but at the end of the day (pun unintended) your brain and rest of body will usually need 6+ hours of sleep to regenerate. That's what extended fami"

Also very diligently add zinc and p5p(active b6) if possible B6 being it synergized really well will magnesium and zinc alike

But prioritize zinc above anything in this list of things i gave you NAC is a great tool, but it uses up zinc at a very alarming rate. It's all because it induces the sulfur protein metallothionein which activates the second stage of methylation "THE SULFUR DRAIN" where all the excess homocysteine turns into something more productive other than heart attacks markers and actively detoxifies the body from aldehyde(other byproducts alike) and heavy metals. I found the effects of NAC to be strongly increased and amplified with zinc. I preferably like gettin"

  • sourceThread: "r/StackAdvice" permalink: "https://www.reddit.com/r/StackAdvice/comments/abwvyt/good_stack_for_gut_health/ed3u1zg/" score: 7 createdAt: "2019-01-02T21:57:06Z" authorHandle: "e32ee2ff" isOriginalPoster: false isPostBody: false postTitle: null wordCount: 112 excerpt: "I found pretty great results in taking Zinc-Carnosine to fix some gut issues I'd been having. It has some reasonable evidence of restoring small bowel integrity. I did have a bad migraine around the time I was taking it though (and hadn't had one for years prior)--but don't know if it's related.

Long term I've found a lot of value in eating wild fermented foods every day (I ferment lacto-bacteria rich vegetables, mainly pickled cucumbers and sauerkraut). I've read that a lot of the beneficial effect of probiotics or alive foods is in a gene exchange mechanism in the gut, so the more wild foods the better (and fermented foods are delicious)."

Acidify your stomach with zinc carnosine, And drink lemon water which has low ph. Or use betaine hcl.

Once food passes stomach it shouldnt make you throw up"

  • sourceThread: "r/longevity" permalink: "https://www.reddit.com/r/longevity/comments/53tfu6/_/d7w9pne" score: 7 createdAt: "2016-09-21T17:25:46Z" authorHandle: "2fdf6d75" isOriginalPoster: false isPostBody: false postTitle: null wordCount: 56 excerpt: "Dasatinib - Senescent clearence in fat cells, Quercetin - Senescent clearence in muscle or bone (not sure), Nicotinamide Riboside - boosting NAD levels, Carnosine - AGE inhibitor, MitoQ - Mitochondrial antioxidant. Not sure which of these are helpfull for younger healthy people and do they slow aging at all if you are under 35 and healthy."
  • sourceThread: "r/DrugNerds" permalink: "https://www.reddit.com/r/DrugNerds/comments/8j6h0s/phenibut_improves_selfcontrol_sustained_directed/dyy1wer/" score: 6 createdAt: "2018-05-14T05:12:14Z" authorHandle: "122df50a" isOriginalPoster: false isPostBody: false postTitle: null wordCount: 26 excerpt: "Phenibut related drugs have recently shown promise in autism so it makes sense this may help.

Carnosine also has some good research in autism and ocd."

Edit: Have to add Bpc-157. I know we are going into double digits here, but after 20 years of experimenting with hundreds of supplements, these are what I've found to have a legit, non-placebo, positive impact on my health."

  • sourceThread: "r/StackAdvice" permalink: "https://www.reddit.com/r/StackAdvice/comments/ffzp97/ultimate_longevity_and_anticancer_stack/fk1z5w8/" score: 6 createdAt: "2020-03-09T21:36:39Z" authorHandle: "0c6caf34" isOriginalPoster: false isPostBody: false postTitle: null wordCount: 17 excerpt: "Berberine, Carnosine, Fo-Ti, Chaga, Reishi, Agmatine or Citrulline, Maritime Pine Bark Extract, Shilajit, LLLT, Sauna, Cryotherapy, etc."
  • sourceThread: "r/longevity" permalink: "https://www.reddit.com/r/longevity/comments/5btp7g/_/d9s5ssd" score: 6 createdAt: "2016-11-09T03:32:33Z" authorHandle: "6430185f" isOriginalPoster: false isPostBody: false postTitle: null wordCount: 480 excerpt: "I realize that there are a lot of ideas and treatments I need to research. Here is my collection of things to look up that may or may not have evidence to support its use:

Drug and Supplement tx:

1.Metformin

2.Rapamycin

3.Dasatinib - Senescent clearance in fat cells,

4.Quercetin - Senescent clearance in muscle or bone (not sure),

5.Nicotinamide Riboside - boosting NAD levels, Carnosine - AGE inhibitor,

6.MitoQ - Mitochondrial antioxidant.

7.C60oo?

8.Vitamin D3: 2000iu daily without needing labs... 5000iu with labs

9.Glucosamine? Sulfate vs HCl?

10.Tumeric? turmerone (compound found within turmeric). Turmeric also has curcumin which is considered an anti-inflammatory.

11.Resveratrol

12.Fish oil? High dose at least 2g Omega3 offers anti-inflammatory and triglycerides"

Is it possible at this point to know at which threshold NO becomes a neurotoxin as opposed to a neuroprotectant? The original paper suggests NOS inhibitors like curcumin, ALCAR and l-carnosine. The 2015 paper suggests potassium channel blockers if I'm not mistaken. I'm just alarmed that NO could be neurotoxic at all and I wonder if polysupplement use could have a deleterious effect in this regard (for example agmatine, citrulline, jiaogulan, gynostemma, the occasional PDE5"

This is very similar to my stack but mine includes 500mg-1000mg of L-Phenylalanine. My dose of bromantane is a bit higher, perhaps I should lower it.

Right now I'm interested in adding in something that can inhibit dopamine beta hydroxylase, the enzyme that turns dopamine into noradrenaline. Going to try catuaba bark first, then perhaps L-Carnosine and Beta Alanine"

  • sourceThread: "r/StackAdvice" permalink: "https://www.reddit.com/r/StackAdvice/comments/r3elu4/30_year_old_male_first_stack_options/hmafdi6/" score: 5 createdAt: "2021-11-27T16:38:25Z" authorHandle: "4b06efbd" isOriginalPoster: false isPostBody: false postTitle: null wordCount: 134 excerpt: "Hey, I am close to your age, here is mine(some will double up in categories): Cognitive/health: NAC, sulforaphane, glycine(glutathione enhancers), ALCAR, Agmatine, Creatine, NMN, NR, Resveratrol , phosphatidyl serine, APC, huperzine A Muscle/health: Creatine, Agmatine, ALCAR, beta-alanine(also good anti ageing search L carnosine gyroprotector and carnosine beta alanine synthesis -- its better than just supplementing carnosine).

I have tried and done many, including many more experimental nuanced russian neuro-peptides etc, but i feel this one is a good balance.

In terms of the effects, mostly about the alleged health affects and cognitive boost -- but i felt a subjective change also. There is 0 guarantee or expectations you can consciously pin point the improvements even if they occur -"

The last three days I've taken half my dose, and started BPC157 + TB500 + Mk677. I'm guessing the Dexedrine fucks up ghrelin levels badly, because I haven't really felt the MK677 hunger everyone talks about. I can eat more, but it's a subtle effect (on 25mg).

Before tapering off further, I want to fix my sleep schedule (will try Epitalon) and work out consistently.

​

Aside from peptides, here are some oral supplements I'm using for this intervention;

Sleep + cortisol stack:

  • Lemon balm extract, L-theanine, magnesiums (bis/glycinate, threonate, taurate), CBD, Holy basil, Magnolia, Valerian, Silexan, glycine, carnosine
  • Guanfacine IR (just 0.5mg)

Cognitive/mental stack:

  • Glu"
    • sourceThread: "r/DrugNerds" permalink: "https://www.reddit.com/r/DrugNerds/comments/6f5bl0/_/difjjdw" score: 4 createdAt: "2017-06-04T03:31:05Z" authorHandle: "94540aee" isOriginalPoster: false isPostBody: false postTitle: null wordCount: 163 excerpt: ""L-Carnosine, a dipeptide, can enhance frontal lobe function or be neuroprotective. It can also correlate with γ-aminobutyric acid (GABA)-homocarnosine interaction, with possible anticonvulsive effects. We investigated 31 children with autistic spectrum disorders in an 8-week, double-blinded study to determine if 800 mg L-carnosine daily would result in observable changes versus placebo. Outcome measures were the Childhood Autism Rating Scale, the Gilliam Autism Rating Scale, the Expressive and Receptive One-Word Picture Vocabulary tests, and Clinical Global Impressions of Change. Children on placebo did not show statistically significant changes. After 8 weeks on L-carnosine, children showed statistically significant improvements on the Gilliam Autism Rating Scale (total score and the Beh" attribution: sources:
      • name: "dopamine.club" role: "community aggregate stats, dose distribution, stack synergies, AI-seeded interactions" url: "https://dopamine.club/substances/carnosine/"
      • name: "reddit" role: "paragraph-level community anecdotes" url: "https://reddit.com" text: "Aggregated from creator-curated and community sources. Verify dose, sourcing, and safety before use."

=== community-data-block:end ===

gently petering out to 8 hours.

Zynamite 300mg, Theacrine 300mg, Caffeine 50mg, GS15-4 100mg, Alpha-GPC 300mg, CDP-Choline 150mg, ALCAR 1g, Magnesium (ATA-Mg is worth the money IMO but L-theronate is very good, I'm also very impressed with bio-optimisers blend of 7. Doses will vary but tend to the high to very high,. Rhodiola Rosea (preferably in 5-2 but 3-1 is fine) in 250-500mg. B-vitamin stack (again doses vary, worth adding in modified b-vitamins IMO, sulbutiamine, emoxypine, benfotiamine). NALT 500mg, DL-Phenylaline 250mg, L-Phenylaline 250mg, EnXtra 300mg, Primavie 200mg, L-Tryptophan 300mg, Trans-Reservatrol 250mg, NMN 500mg, L-theanine 400mg. I could go on, but this is a good example; some of these you might want to tak"

  • sourceThread: "r/StackAdvice" permalink: "https://www.reddit.com/r/StackAdvice/comments/i5kw8p/too_many_stimulants/g0ptr8z/" score: 9 createdAt: "2020-08-07T20:08:59Z" authorHandle: "c633dad2" isOriginalPoster: false isPostBody: false postTitle: null wordCount: 33 excerpt: "Uh u should definitely be on a basic cardioprotective stack with creatine/lysine/carnosine/TAURINE as a amino acid base and NMN/CoQ10/Omega3's/Berberine. Make sure you get enough potassium as well. really surprised you dont use taurine"

  • sourceThread: "r/longevity" permalink: "https://www.reddit.com/r/longevity/comments/7djbcs/the_results_of_most_potential_biomarkers_of_aging/dpzibkw/" score: 8 createdAt: "2017-11-18T01:23:28Z" authorHandle: "03cb838f" isOriginalPoster: false isPostBody: false postTitle: null wordCount: 86 excerpt: "Not surprising, really. Aging is a complex thing. My first telomere test showed that I had the length of a 90 year old. Well I am certainly far from being 90. So using that marker alone as an indication of age would be inaccurate. Scary as hell, though. After a single cycle of Epitalon, Thymalin, GHK-Cu, and L-carnosine, my results showed the length of a 26 year old. My age didn't change, but the marker did. I think environmental factors affect all these markers a lot."

  • sourceThread: "r/Nootropics" permalink: "https://www.reddit.com/r/Nootropics/comments/vop8nk/reliable_source_of_oxytocin_in_the_uk/iefeywf/" score: 7 createdAt: "2022-07-01T08:17:16Z" authorHandle: "6b37059e" isOriginalPoster: false isPostBody: false postTitle: null wordCount: 26 excerpt: "A lot of other supplements can increase oxytocin. 5-HT2A and 5-HT1A agonist can increase oxytocin. Some on top of my mind are l-carnosine, oleoethylamide, yokukansan, psychedelic"

  • sourceThread: "r/Nootropics" permalink: "https://www.reddit.com/r/Nootropics/comments/vgazjt/minerals_neurological_functions/id1y29i/" score: 7 createdAt: "2022-06-20T12:49:55Z" authorHandle: "7321faa3" isOriginalPoster: false isPostBody: false postTitle: null wordCount: 230 excerpt: "Get more:

  • Zinc (Zinc-Carnosine is the best form)

  • Heme-Iron (I use the brand Proferrin, once every 2-3 days)

  • Copper Glycinate (Once every 2 days)

  • Magnesium Threonate or Magnesium Glycinate (1-3x a day or as needed)

  • Lycopene (Can get it from the drink V8, 2-3x a day)

You should also get more antioxidants, plenty of vitamin C but maybe try an NAC supplement too. Glutamate is a co-factor for glutathione synthesis, a powerful antioxidant, and NAC basically lowers glutamate levels by converting it into glutathione... It can help a lot.

Pair the NAC with magnesium glycinate and/or glycine, and vitamin c to make sure it's most effective.

Get more flavonoids and polyphenols, like quercetin, multiple times a day. Home-brewed coffee, tea, and dark chocolate are the best sources"

Dopamine beta-hydroxylase is responsible for the conversion of dopamine to norepinephrine

In theory this would lead to more available dopamine and could lower symptoms of physical anxiety with less norepinephrine

Beta alanine is the rate limiter between the two in carnosine production

I'm 95% sure what I just said is completely true, but all from memory, so do your own fact check

TLDR- beta alanine could increase dopamine and lower norepinephrine

Get sustained release beta alanine, I believe it's called Carnosyn, to avoid an itchy butthole (never experienced it myself, just saying)"

  • sourceThread: "r/StackAdvice" permalink: "https://www.reddit.com/r/StackAdvice/comments/ydpo1p/nootropics_for_combating_sleep_deprivation/itukj4c/" score: 7 createdAt: "2022-10-26T12:48:04Z" authorHandle: "efa21d92" isOriginalPoster: false isPostBody: false postTitle: null wordCount: 140 excerpt: "Modafinil and variants downregulate emotional affect though, which may not be desired when bonding with a newborn. Might be possible to ameliorate by supplementing with oxytocin, but as yet unaware of any research to support this speculation.

Other than that, take from me... you get used to the sleep deprivation after a while and working out care schedule shifts with your partner help a great deal. Inviting grandma to take over for a few nights would also go down well with everyone involved if that's an option for you.

Why no NAC + vitamin C and alpha lipoic acid? Carnosine + aspirin can be quite helpful for neuroinflammation tiredness too, but at the end of the day (pun unintended) your brain and rest of body will usually need 6+ hours of sleep to regenerate. That's what extended fami"

Also very diligently add zinc and p5p(active b6) if possible B6 being it synergized really well will magnesium and zinc alike

But prioritize zinc above anything in this list of things i gave you NAC is a great tool, but it uses up zinc at a very alarming rate. It's all because it induces the sulfur protein metallothionein which activates the second stage of methylation "THE SULFUR DRAIN" where all the excess homocysteine turns into something more productive other than heart attacks markers and actively detoxifies the body from aldehyde(other byproducts alike) and heavy metals. I found the effects of NAC to be strongly increased and amplified with zinc. I preferably like gettin"

  • sourceThread: "r/StackAdvice" permalink: "https://www.reddit.com/r/StackAdvice/comments/abwvyt/good_stack_for_gut_health/ed3u1zg/" score: 7 createdAt: "2019-01-02T21:57:06Z" authorHandle: "e32ee2ff" isOriginalPoster: false isPostBody: false postTitle: null wordCount: 112 excerpt: "I found pretty great results in taking Zinc-Carnosine to fix some gut issues I'd been having. It has some reasonable evidence of restoring small bowel integrity. I did have a bad migraine around the time I was taking it though (and hadn't had one for years prior)--but don't know if it's related.

Long term I've found a lot of value in eating wild fermented foods every day (I ferment lacto-bacteria rich vegetables, mainly pickled cucumbers and sauerkraut). I've read that a lot of the beneficial effect of probiotics or alive foods is in a gene exchange mechanism in the gut, so the more wild foods the better (and fermented foods are delicious)."

Acidify your stomach with zinc carnosine, And drink lemon water which has low ph. Or use betaine hcl.

Once food passes stomach it shouldnt make you throw up"

  • sourceThread: "r/longevity" permalink: "https://www.reddit.com/r/longevity/comments/53tfu6/_/d7w9pne" score: 7 createdAt: "2016-09-21T17:25:46Z" authorHandle: "2fdf6d75" isOriginalPoster: false isPostBody: false postTitle: null wordCount: 56 excerpt: "Dasatinib - Senescent clearence in fat cells, Quercetin - Senescent clearence in muscle or bone (not sure), Nicotinamide Riboside - boosting NAD levels, Carnosine - AGE inhibitor, MitoQ - Mitochondrial antioxidant. Not sure which of these are helpfull for younger healthy people and do they slow aging at all if you are under 35 and healthy."
  • sourceThread: "r/DrugNerds" permalink: "https://www.reddit.com/r/DrugNerds/comments/8j6h0s/phenibut_improves_selfcontrol_sustained_directed/dyy1wer/" score: 6 createdAt: "2018-05-14T05:12:14Z" authorHandle: "122df50a" isOriginalPoster: false isPostBody: false postTitle: null wordCount: 26 excerpt: "Phenibut related drugs have recently shown promise in autism so it makes sense this may help.

Carnosine also has some good research in autism and ocd."

Edit: Have to add Bpc-157. I know we are going into double digits here, but after 20 years of experimenting with hundreds of supplements, these are what I've found to have a legit, non-placebo, positive impact on my health."

  • sourceThread: "r/StackAdvice" permalink: "https://www.reddit.com/r/StackAdvice/comments/ffzp97/ultimate_longevity_and_anticancer_stack/fk1z5w8/" score: 6 createdAt: "2020-03-09T21:36:39Z" authorHandle: "0c6caf34" isOriginalPoster: false isPostBody: false postTitle: null wordCount: 17 excerpt: "Berberine, Carnosine, Fo-Ti, Chaga, Reishi, Agmatine or Citrulline, Maritime Pine Bark Extract, Shilajit, LLLT, Sauna, Cryotherapy, etc."
  • sourceThread: "r/longevity" permalink: "https://www.reddit.com/r/longevity/comments/5btp7g/_/d9s5ssd" score: 6 createdAt: "2016-11-09T03:32:33Z" authorHandle: "6430185f" isOriginalPoster: false isPostBody: false postTitle: null wordCount: 480 excerpt: "I realize that there are a lot of ideas and treatments I need to research. Here is my collection of things to look up that may or may not have evidence to support its use:

Drug and Supplement tx:

1.Metformin

2.Rapamycin

3.Dasatinib - Senescent clearance in fat cells,

4.Quercetin - Senescent clearance in muscle or bone (not sure),

5.Nicotinamide Riboside - boosting NAD levels, Carnosine - AGE inhibitor,

6.MitoQ - Mitochondrial antioxidant.

7.C60oo?

8.Vitamin D3: 2000iu daily without needing labs... 5000iu with labs

9.Glucosamine? Sulfate vs HCl?

10.Tumeric? turmerone (compound found within turmeric). Turmeric also has curcumin which is considered an anti-inflammatory.

11.Resveratrol

12.Fish oil? High dose at least 2g Omega3 offers anti-inflammatory and triglycerides"

Is it possible at this point to know at which threshold NO becomes a neurotoxin as opposed to a neuroprotectant? The original paper suggests NOS inhibitors like curcumin, ALCAR and l-carnosine. The 2015 paper suggests potassium channel blockers if I'm not mistaken. I'm just alarmed that NO could be neurotoxic at all and I wonder if polysupplement use could have a deleterious effect in this regard (for example agmatine, citrulline, jiaogulan, gynostemma, the occasional PDE5"

This is very similar to my stack but mine includes 500mg-1000mg of L-Phenylalanine. My dose of bromantane is a bit higher, perhaps I should lower it.

Right now I'm interested in adding in something that can inhibit dopamine beta hydroxylase, the enzyme that turns dopamine into noradrenaline. Going to try catuaba bark first, then perhaps L-Carnosine and Beta Alanine"

  • sourceThread: "r/StackAdvice" permalink: "https://www.reddit.com/r/StackAdvice/comments/r3elu4/30_year_old_male_first_stack_options/hmafdi6/" score: 5 createdAt: "2021-11-27T16:38:25Z" authorHandle: "4b06efbd" isOriginalPoster: false isPostBody: false postTitle: null wordCount: 134 excerpt: "Hey, I am close to your age, here is mine(some will double up in categories): Cognitive/health: NAC, sulforaphane, glycine(glutathione enhancers), ALCAR, Agmatine, Creatine, NMN, NR, Resveratrol , phosphatidyl serine, APC, huperzine A Muscle/health: Creatine, Agmatine, ALCAR, beta-alanine(also good anti ageing search L carnosine gyroprotector and carnosine beta alanine synthesis -- its better than just supplementing carnosine).

I have tried and done many, including many more experimental nuanced russian neuro-peptides etc, but i feel this one is a good balance.

In terms of the effects, mostly about the alleged health affects and cognitive boost -- but i felt a subjective change also. There is 0 guarantee or expectations you can consciously pin point the improvements even if they occur -"

The last three days I've taken half my dose, and started BPC157 + TB500 + Mk677. I'm guessing the Dexedrine fucks up ghrelin levels badly, because I haven't really felt the MK677 hunger everyone talks about. I can eat more, but it's a subtle effect (on 25mg).

Before tapering off further, I want to fix my sleep schedule (will try Epitalon) and work out consistently.

​

Aside from peptides, here are some oral supplements I'm using for this intervention;

Sleep + cortisol stack:

  • Lemon balm extract, L-theanine, magnesiums (bis/glycinate, threonate, taurate), CBD, Holy basil, Magnolia, Valerian, Silexan, glycine, carnosine
  • Guanfacine IR (just 0.5mg)

Cognitive/mental stack:

  • Glu"
    • sourceThread: "r/DrugNerds" permalink: "https://www.reddit.com/r/DrugNerds/comments/6f5bl0/_/difjjdw" score: 4 createdAt: "2017-06-04T03:31:05Z" authorHandle: "94540aee" isOriginalPoster: false isPostBody: false postTitle: null wordCount: 163 excerpt: ""L-Carnosine, a dipeptide, can enhance frontal lobe function or be neuroprotective. It can also correlate with γ-aminobutyric acid (GABA)-homocarnosine interaction, with possible anticonvulsive effects. We investigated 31 children with autistic spectrum disorders in an 8-week, double-blinded study to determine if 800 mg L-carnosine daily would result in observable changes versus placebo. Outcome measures were the Childhood Autism Rating Scale, the Gilliam Autism Rating Scale, the Expressive and Receptive One-Word Picture Vocabulary tests, and Clinical Global Impressions of Change. Children on placebo did not show statistically significant changes. After 8 weeks on L-carnosine, children showed statistically significant improvements on the Gilliam Autism Rating Scale (total score and the Beh" attribution: sources:
      • name: "dopamine.club" role: "community aggregate stats, dose distribution, stack synergies, AI-seeded interactions" url: "https://dopamine.club/substances/carnosine/"
      • name: "reddit" role: "paragraph-level community anecdotes" url: "https://reddit.com" text: "Aggregated from creator-curated and community sources. Verify dose, sourcing, and safety before use."

=== community-data-block:end ===

gently petering out to 8 hours.

Zynamite 300mg, Theacrine 300mg, Caffeine 50mg, GS15-4 100mg, Alpha-GPC 300mg, CDP-Choline 150mg, ALCAR 1g, Magnesium (ATA-Mg is worth the money IMO but L-theronate is very good, I'm also very impressed with bio-optimisers blend of 7. Doses will vary but tend to the high to very high,. Rhodiola Rosea (preferably in 5-2 but 3-1 is fine) in 250-500mg. B-vitamin stack (again doses vary, worth adding in modified b-vitamins IMO, sulbutiamine, emoxypine, benfotiamine). NALT 500mg, DL-Phenylaline 250mg, L-Phenylaline 250mg, EnXtra 300mg, Primavie 200mg, L-Tryptophan 300mg, Trans-Reservatrol 250mg, NMN 500mg, L-theanine 400mg. I could go on, but this is a good example; some of these you might want to tak"

  • sourceThread: "r/StackAdvice" permalink: "https://www.reddit.com/r/StackAdvice/comments/i5kw8p/too_many_stimulants/g0ptr8z/" score: 9 createdAt: "2020-08-07T20:08:59Z" authorHandle: "c633dad2" isOriginalPoster: false isPostBody: false postTitle: null wordCount: 33 excerpt: "Uh u should definitely be on a basic cardioprotective stack with creatine/lysine/carnosine/TAURINE as a amino acid base and NMN/CoQ10/Omega3's/Berberine. Make sure you get enough potassium as well. really surprised you dont use taurine"

  • sourceThread: "r/longevity" permalink: "https://www.reddit.com/r/longevity/comments/7djbcs/the_results_of_most_potential_biomarkers_of_aging/dpzibkw/" score: 8 createdAt: "2017-11-18T01:23:28Z" authorHandle: "03cb838f" isOriginalPoster: false isPostBody: false postTitle: null wordCount: 86 excerpt: "Not surprising, really. Aging is a complex thing. My first telomere test showed that I had the length of a 90 year old. Well I am certainly far from being 90. So using that marker alone as an indication of age would be inaccurate. Scary as hell, though. After a single cycle of Epitalon, Thymalin, GHK-Cu, and L-carnosine, my results showed the length of a 26 year old. My age didn't change, but the marker did. I think environmental factors affect all these markers a lot."

  • sourceThread: "r/Nootropics" permalink: "https://www.reddit.com/r/Nootropics/comments/vop8nk/reliable_source_of_oxytocin_in_the_uk/iefeywf/" score: 7 createdAt: "2022-07-01T08:17:16Z" authorHandle: "6b37059e" isOriginalPoster: false isPostBody: false postTitle: null wordCount: 26 excerpt: "A lot of other supplements can increase oxytocin. 5-HT2A and 5-HT1A agonist can increase oxytocin. Some on top of my mind are l-carnosine, oleoethylamide, yokukansan, psychedelic"

  • sourceThread: "r/Nootropics" permalink: "https://www.reddit.com/r/Nootropics/comments/vgazjt/minerals_neurological_functions/id1y29i/" score: 7 createdAt: "2022-06-20T12:49:55Z" authorHandle: "7321faa3" isOriginalPoster: false isPostBody: false postTitle: null wordCount: 230 excerpt: "Get more:

  • Zinc (Zinc-Carnosine is the best form)

  • Heme-Iron (I use the brand Proferrin, once every 2-3 days)

  • Copper Glycinate (Once every 2 days)

  • Magnesium Threonate or Magnesium Glycinate (1-3x a day or as needed)

  • Lycopene (Can get it from the drink V8, 2-3x a day)

You should also get more antioxidants, plenty of vitamin C but maybe try an NAC supplement too. Glutamate is a co-factor for glutathione synthesis, a powerful antioxidant, and NAC basically lowers glutamate levels by converting it into glutathione... It can help a lot.

Pair the NAC with magnesium glycinate and/or glycine, and vitamin c to make sure it's most effective.

Get more flavonoids and polyphenols, like quercetin, multiple times a day. Home-brewed coffee, tea, and dark chocolate are the best sources"

Dopamine beta-hydroxylase is responsible for the conversion of dopamine to norepinephrine

In theory this would lead to more available dopamine and could lower symptoms of physical anxiety with less norepinephrine

Beta alanine is the rate limiter between the two in carnosine production

I'm 95% sure what I just said is completely true, but all from memory, so do your own fact check

TLDR- beta alanine could increase dopamine and lower norepinephrine

Get sustained release beta alanine, I believe it's called Carnosyn, to avoid an itchy butthole (never experienced it myself, just saying)"

  • sourceThread: "r/StackAdvice" permalink: "https://www.reddit.com/r/StackAdvice/comments/ydpo1p/nootropics_for_combating_sleep_deprivation/itukj4c/" score: 7 createdAt: "2022-10-26T12:48:04Z" authorHandle: "efa21d92" isOriginalPoster: false isPostBody: false postTitle: null wordCount: 140 excerpt: "Modafinil and variants downregulate emotional affect though, which may not be desired when bonding with a newborn. Might be possible to ameliorate by supplementing with oxytocin, but as yet unaware of any research to support this speculation.

Other than that, take from me... you get used to the sleep deprivation after a while and working out care schedule shifts with your partner help a great deal. Inviting grandma to take over for a few nights would also go down well with everyone involved if that's an option for you.

Why no NAC + vitamin C and alpha lipoic acid? Carnosine + aspirin can be quite helpful for neuroinflammation tiredness too, but at the end of the day (pun unintended) your brain and rest of body will usually need 6+ hours of sleep to regenerate. That's what extended fami"

Also very diligently add zinc and p5p(active b6) if possible B6 being it synergized really well will magnesium and zinc alike

But prioritize zinc above anything in this list of things i gave you NAC is a great tool, but it uses up zinc at a very alarming rate. It's all because it induces the sulfur protein metallothionein which activates the second stage of methylation "THE SULFUR DRAIN" where all the excess homocysteine turns into something more productive other than heart attacks markers and actively detoxifies the body from aldehyde(other byproducts alike) and heavy metals. I found the effects of NAC to be strongly increased and amplified with zinc. I preferably like gettin"

  • sourceThread: "r/StackAdvice" permalink: "https://www.reddit.com/r/StackAdvice/comments/abwvyt/good_stack_for_gut_health/ed3u1zg/" score: 7 createdAt: "2019-01-02T21:57:06Z" authorHandle: "e32ee2ff" isOriginalPoster: false isPostBody: false postTitle: null wordCount: 112 excerpt: "I found pretty great results in taking Zinc-Carnosine to fix some gut issues I'd been having. It has some reasonable evidence of restoring small bowel integrity. I did have a bad migraine around the time I was taking it though (and hadn't had one for years prior)--but don't know if it's related.

Long term I've found a lot of value in eating wild fermented foods every day (I ferment lacto-bacteria rich vegetables, mainly pickled cucumbers and sauerkraut). I've read that a lot of the beneficial effect of probiotics or alive foods is in a gene exchange mechanism in the gut, so the more wild foods the better (and fermented foods are delicious)."

Acidify your stomach with zinc carnosine, And drink lemon water which has low ph. Or use betaine hcl.

Once food passes stomach it shouldnt make you throw up"

  • sourceThread: "r/longevity" permalink: "https://www.reddit.com/r/longevity/comments/53tfu6/_/d7w9pne" score: 7 createdAt: "2016-09-21T17:25:46Z" authorHandle: "2fdf6d75" isOriginalPoster: false isPostBody: false postTitle: null wordCount: 56 excerpt: "Dasatinib - Senescent clearence in fat cells, Quercetin - Senescent clearence in muscle or bone (not sure), Nicotinamide Riboside - boosting NAD levels, Carnosine - AGE inhibitor, MitoQ - Mitochondrial antioxidant. Not sure which of these are helpfull for younger healthy people and do they slow aging at all if you are under 35 and healthy."
  • sourceThread: "r/DrugNerds" permalink: "https://www.reddit.com/r/DrugNerds/comments/8j6h0s/phenibut_improves_selfcontrol_sustained_directed/dyy1wer/" score: 6 createdAt: "2018-05-14T05:12:14Z" authorHandle: "122df50a" isOriginalPoster: false isPostBody: false postTitle: null wordCount: 26 excerpt: "Phenibut related drugs have recently shown promise in autism so it makes sense this may help.

Carnosine also has some good research in autism and ocd."

Edit: Have to add Bpc-157. I know we are going into double digits here, but after 20 years of experimenting with hundreds of supplements, these are what I've found to have a legit, non-placebo, positive impact on my health."

  • sourceThread: "r/StackAdvice" permalink: "https://www.reddit.com/r/StackAdvice/comments/ffzp97/ultimate_longevity_and_anticancer_stack/fk1z5w8/" score: 6 createdAt: "2020-03-09T21:36:39Z" authorHandle: "0c6caf34" isOriginalPoster: false isPostBody: false postTitle: null wordCount: 17 excerpt: "Berberine, Carnosine, Fo-Ti, Chaga, Reishi, Agmatine or Citrulline, Maritime Pine Bark Extract, Shilajit, LLLT, Sauna, Cryotherapy, etc."
  • sourceThread: "r/longevity" permalink: "https://www.reddit.com/r/longevity/comments/5btp7g/_/d9s5ssd" score: 6 createdAt: "2016-11-09T03:32:33Z" authorHandle: "6430185f" isOriginalPoster: false isPostBody: false postTitle: null wordCount: 480 excerpt: "I realize that there are a lot of ideas and treatments I need to research. Here is my collection of things to look up that may or may not have evidence to support its use:

Drug and Supplement tx:

1.Metformin

2.Rapamycin

3.Dasatinib - Senescent clearance in fat cells,

4.Quercetin - Senescent clearance in muscle or bone (not sure),

5.Nicotinamide Riboside - boosting NAD levels, Carnosine - AGE inhibitor,

6.MitoQ - Mitochondrial antioxidant.

7.C60oo?

8.Vitamin D3: 2000iu daily without needing labs... 5000iu with labs

9.Glucosamine? Sulfate vs HCl?

10.Tumeric? turmerone (compound found within turmeric). Turmeric also has curcumin which is considered an anti-inflammatory.

11.Resveratrol

12.Fish oil? High dose at least 2g Omega3 offers anti-inflammatory and triglycerides"

Is it possible at this point to know at which threshold NO becomes a neurotoxin as opposed to a neuroprotectant? The original paper suggests NOS inhibitors like curcumin, ALCAR and l-carnosine. The 2015 paper suggests potassium channel blockers if I'm not mistaken. I'm just alarmed that NO could be neurotoxic at all and I wonder if polysupplement use could have a deleterious effect in this regard (for example agmatine, citrulline, jiaogulan, gynostemma, the occasional PDE5"

This is very similar to my stack but mine includes 500mg-1000mg of L-Phenylalanine. My dose of bromantane is a bit higher, perhaps I should lower it.

Right now I'm interested in adding in something that can inhibit dopamine beta hydroxylase, the enzyme that turns dopamine into noradrenaline. Going to try catuaba bark first, then perhaps L-Carnosine and Beta Alanine"

  • sourceThread: "r/StackAdvice" permalink: "https://www.reddit.com/r/StackAdvice/comments/r3elu4/30_year_old_male_first_stack_options/hmafdi6/" score: 5 createdAt: "2021-11-27T16:38:25Z" authorHandle: "4b06efbd" isOriginalPoster: false isPostBody: false postTitle: null wordCount: 134 excerpt: "Hey, I am close to your age, here is mine(some will double up in categories): Cognitive/health: NAC, sulforaphane, glycine(glutathione enhancers), ALCAR, Agmatine, Creatine, NMN, NR, Resveratrol , phosphatidyl serine, APC, huperzine A Muscle/health: Creatine, Agmatine, ALCAR, beta-alanine(also good anti ageing search L carnosine gyroprotector and carnosine beta alanine synthesis -- its better than just supplementing carnosine).

I have tried and done many, including many more experimental nuanced russian neuro-peptides etc, but i feel this one is a good balance.

In terms of the effects, mostly about the alleged health affects and cognitive boost -- but i felt a subjective change also. There is 0 guarantee or expectations you can consciously pin point the improvements even if they occur -"

The last three days I've taken half my dose, and started BPC157 + TB500 + Mk677. I'm guessing the Dexedrine fucks up ghrelin levels badly, because I haven't really felt the MK677 hunger everyone talks about. I can eat more, but it's a subtle effect (on 25mg).

Before tapering off further, I want to fix my sleep schedule (will try Epitalon) and work out consistently.

​

Aside from peptides, here are some oral supplements I'm using for this intervention;

Sleep + cortisol stack:

  • Lemon balm extract, L-theanine, magnesiums (bis/glycinate, threonate, taurate), CBD, Holy basil, Magnolia, Valerian, Silexan, glycine, carnosine
  • Guanfacine IR (just 0.5mg)

Cognitive/mental stack:

  • Glu"
    • sourceThread: "r/DrugNerds" permalink: "https://www.reddit.com/r/DrugNerds/comments/6f5bl0/_/difjjdw" score: 4 createdAt: "2017-06-04T03:31:05Z" authorHandle: "94540aee" isOriginalPoster: false isPostBody: false postTitle: null wordCount: 163 excerpt: ""L-Carnosine, a dipeptide, can enhance frontal lobe function or be neuroprotective. It can also correlate with γ-aminobutyric acid (GABA)-homocarnosine interaction, with possible anticonvulsive effects. We investigated 31 children with autistic spectrum disorders in an 8-week, double-blinded study to determine if 800 mg L-carnosine daily would result in observable changes versus placebo. Outcome measures were the Childhood Autism Rating Scale, the Gilliam Autism Rating Scale, the Expressive and Receptive One-Word Picture Vocabulary tests, and Clinical Global Impressions of Change. Children on placebo did not show statistically significant changes. After 8 weeks on L-carnosine, children showed statistically significant improvements on the Gilliam Autism Rating Scale (total score and the Beh" attribution: sources:
      • name: "dopamine.club" role: "community aggregate stats, dose distribution, stack synergies, AI-seeded interactions" url: "https://dopamine.club/substances/carnosine/"
      • name: "reddit" role: "paragraph-level community anecdotes" url: "https://reddit.com" text: "Aggregated from creator-curated and community sources. Verify dose, sourcing, and safety before use."

=== community-data-block:end ===

What to Expect

  • Week 1
    Tolerability and dose-response.
  • Week 2-4
    Early effect window.
  • Week 4-8
    Peak benefit assessment.
  • Week 8+
    Cycle decision point.
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