A large number of companies have substantially hiked prices on drugs that used to be cheap. In most of these cases, the FDA had recently acted to reduce competition, effectively giving companies monopolies.

EpiPen

The 600% EpiPen price hikes came on the heels of the FDA recalling a competitor's product because the competitor's product sometimes delivered an inaccurate dose of epinephrine (as it turns out, the competitor's product was no more inaccurate than Mylan's EpiPen, so why did the FDA single out the competitor...). The competitor subsequently left the market, and EpiPen faced minimal competition thereafter, allowing Mylan to hike prices. Also, the fact that the EpiPen i"

• sourceThread: "r/DrugNerds" permalink: "https://www.reddit.com/r/DrugNerds/comments/mxccss/an_idea_of_deliberately_pollinating_a_female/gvnint8/" score: 4 createdAt: "2021-04-24T05:37:11Z" authorHandle: "29323178" isOriginalPoster: false isPostBody: false postTitle: null wordCount: 31 excerpt: "Look into polyploidy. That's how seedless watermelons, grapes, and bananas are made. Colchicine is used to induce polyploidy and is reasonably common, although it is technically Rx only in the US."
• sourceThread: "r/Nootropics" permalink: "https://www.reddit.com/r/Nootropics/comments/51c61o/_/d7bzuju" score: 3 createdAt: "2016-09-06T21:31:40Z" authorHandle: "0c366257" isOriginalPoster: false isPostBody: false postTitle: null wordCount: 290 excerpt: "> Why not actually subsidize them then?

Because it is incredibly hard for the governments to pick winners.

It's easier to say "You get to charge what you want for around a decade if you develop a new drug." Companies will spend money and work very hard to develop drugs that they think will get through FDA trials and actually work well enough that customers will want to pay for it. In particular, they are willing to spend as much on research for a particular treatment as they think customers would be willing to pay, which is approximately the value of the drug. But what is the alternative? Government bureaucrats looking over a lot of research and deciding which products are worth the 2 billion dollars to push through FDA trials? You're kidding yourself if you think the bureaucrats"

• sourceThread: "r/Nootropics" permalink: "https://www.reddit.com/r/Nootropics/comments/54n0mv/_/d83a71j" score: 2 createdAt: "2016-09-26T22:33:36Z" authorHandle: "f569a02d" isOriginalPoster: false isPostBody: false postTitle: null wordCount: 88 excerpt: ">Central administration of colchicine is well known to cause cognitive impairment and oxidative damage, which simulates sporadic dementia of the Alzheimer type in humans.

these kinds of proxies (simulating dementia) are not often accurate across all research areas.

Since we don't know if this is an accurate proxy in this case we wait for human trials.

> Chronic treatment with naringin caused significant improvement in the cognitive performance and attenuated oxidative damage.

this is encouraging for a number of conditions (including stress) where oxidative damage is a thing."

• sourceThread: "r/Nootropics" permalink: "https://www.reddit.com/r/Nootropics/comments/51c61o/_/d7d0u46" score: 2 createdAt: "2016-09-07T17:16:03Z" authorHandle: "0c366257" isOriginalPoster: false isPostBody: false postTitle: null wordCount: 200 excerpt: "Yeah. Most drugs are extremely cheap to manufacture (exceptions can include large, complex molecules, like antibodies) when manufactured on a large scale. Consequently, generic OTC drugs tend to be extremely cheap. For example, you can get 1000 pills of ibuprofen for $10.

As a rule, high drug prices indicate that some law or regulation prevents competition. The patent system does this, but patents are the carrot on the end of a stick. The possibility of a patent (or exclusivity) induces pharmaceutical companies to invest the billions of dollars necessary to bring a drug through the onerous FDA approval process.

The problem is when laws and regulation bar competition for drugs that were developed a long time ago. There is no reason for consumers to pay 26 times the cost for Colc"

• sourceThread: "r/DrugNerds" permalink: "https://www.reddit.com/r/DrugNerds/comments/mxccss/an_idea_of_deliberately_pollinating_a_female/gvnxujx/" score: 2 createdAt: "2021-04-24T09:34:18Z" authorHandle: "90e9d5ad" isOriginalPoster: false isPostBody: false postTitle: null wordCount: 22 excerpt: "You can extract colchicine from the root of the crocus plant, I believe. Toxic if ingested but might work for inducing polyploidy"
• sourceThread: "r/Biohackers" permalink: "https://www.reddit.com/r/Biohackers/comments/156j88d/whats_essential_to_you_that_most_people_dont_even/jt2fg2p/" score: 2 createdAt: "2023-07-23T01:06:28Z" authorHandle: "68dce4e4" isOriginalPoster: false isPostBody: false postTitle: null wordCount: 637 excerpt: "Does Vitamin C Influence Neurodegenerative Diseases and Psychiatric Disorders?

Vitamin C (Vit C) is considered to be a vital antioxidant molecule in the brain. Intracellular Vit C helps maintain integrity and function of several processes in the central nervous system (CNS), including neuronal maturation and differentiation, myelin formation, synthesis of catecholamine, modulation of neurotransmission and antioxidant protection.

The importance of Vit C for CNS function has been proven by the fact that targeted deletion of the sodium-vitamin C co-transporter in mice results in widespread cerebral hemorrhage and death on post-natal day one.

Since neurological diseases are characterized by increased free radical generation and the highest concentrations of Vit C in the body are found"

• sourceThread: "r/Biohackers" permalink: "https://www.reddit.com/r/Biohackers/comments/yl4b7c/mandatory_covid_booster/iuwf6md/" score: 2 createdAt: "2022-11-03T14:48:40Z" authorHandle: "f8eb2fd4" isOriginalPoster: false isPostBody: false postTitle: null wordCount: 44 excerpt: "i'd say everything anti-inflammatory and maybe take aspirin.

For my pericarditis I got aspirin and colchicine (which is only available on doctor's note and gave me heavy diarrhea so I do not recommend)

edit: my pericarditis was probably not vaccine related by the way"

• sourceThread: "r/Biohackers" permalink: "https://www.reddit.com/r/Biohackers/comments/9dh5ji/any_simple_trick_to_biohack_plants/e5hzar7/" score: 2 createdAt: "2018-09-06T15:27:59Z" authorHandle: "ac374d9f" isOriginalPoster: false isPostBody: false postTitle: null wordCount: 52 excerpt: "Induced mutation... Maybe can try Colchicine. What I heard is it can cause non disjunction and increase the set number of the plant's chromosome. You can get colchicine from the corm of a Crocus plant.

Edit : If you found any other methods please update us as well. I'm curious to know" attribution: sources: - name: "dopamine.club" role: "community aggregate stats, dose distribution, stack synergies, AI-seeded interactions" url: "https://dopamine.club/substances/colchicine/" - name: "reddit" role: "paragraph-level community anecdotes" url: "https://reddit.com" text: "Aggregated from creator-curated and community sources. Verify dose, sourcing, and safety before use."

=== community-data-block:end ===