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Surface here is educational only; do not use without medical supervision. Our editorial verdict is SKIP-FOR-NOW — current cost / risk / redundancy puts it below the line.
RAD-140 (Testolone)
Most potent of the common SARMs — strong body comp gains but the harshest HPG suppression in the class plus documented hepatotoxicity case…
Aliases (3)
Overview
What is RAD-140 (Testolone)?
RAD-140 (testolone) is a non-steroidal selective androgen receptor modulator (SARM) developed by Radius Health, originally investigated for breast cancer and muscle wasting. It is not FDA-approved and is banned by WADA.
Key Benefits
Reported to produce strong lean muscle and strength gains comparable to testosterone with reduced androgenic side effects (acne, prostate). Investigated for breast cancer (selective AR antagonism in breast tissue) and Alzheimer's neuroprotection in preclinical models.
Mechanism of Action
Tissue-selective androgen receptor (AR) agonist, with strong agonism in skeletal muscle and bone but mixed activity (sometimes antagonist) in prostate and breast tissue. Recruits coactivators that drive anabolic gene expression including muscle protein synthesis.
Pharmacokinetics
▸ Cycle structure & PCT AAS oral
Ramp dose over week 1, hold steady through cycle weeks. Track baseline labs (TT/FT/E2/SHBG/HCT/lipids/LFTs) at week 0; recheck at week 4 and end-of-cycle.
On the last dose, the ester clears over its half-life window (enanthate = est. 7 days). PCT begins after the active compound has cleared.
Standard PCT is enclomiphene 12.5-25 mg/day or clomid 50/50/25/25 over 4 weeks (or nolvadex 20/20/10/10). HCG bridge optional during cycle to preserve testicular volume + faster restart. Bloodwork at PCT week 4 + 8 to confirm HPG axis recovery (LH, FSH, TT back to baseline).
Quality Indicators
Pharmacy-dispensed, intact packaging
Prescription tablets in original sealed packaging from a licensed pharmacy.
Generic vs branded
Generics are usually fine but bioavailability can vary slightly; track if you switch.
Unbranded blister or counterfeit risk
Counterfeit pharmaceuticals are a known issue; verify pharmacy and lot if buying internationally.
What to Expect
- Onset(week 1-2): Increased aggression, drive, gym output. "Wired" feel that some users like, others find irritable.
- Peak(week 3-6): Significant body composition shift — lean mass gain, fat loss, strength jumps that exceed natural rates. Headaches commonly reported, sometimes d…
Side Effects & Safety
- Common (>10% users): HPG suppression (near-universal at 10mg+), libido changes (initial increase then crash), headaches, aggression/irritability, lipid shifts (HDL drops, LDL rises), elevated liver enzymes (mild-moderate ALT/AST elevation common).
- Less common (1-10%): Hair shedding (AR activation in scalp follicles), acne, sleep disruption, hypertension, gynecomastia (from estrogen rebound or aromatization of recovered T post-cycle).
- Rare-serious (<1% but worth knowing): Drug-induced liver injury (DILI) — published case reports of cholestatic hepatitis requiring hospitalization, some with prolonged recovery. Cardiomyopathy concerns (animal data + case reports). Severe long-term HPG axis dysfunction in some users requiring TRT.
- Specific watch periods: Liver enzymes at week 4 and week 8; lipids at week 8; full hormone panel at week 12 (post-cycle, after PCT).
How was your experience with this compound?
Anonymous · one vote per session · results below at 5+ votes.
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