• Dihydrexidine derivatives

• A-86929 - full agonist with 14-fold selectivity for D1-like receptors over D2

• Dihydrexidine - full agonist with 10-fold selectivity for D1-like receptors over D2 that has been in Phase IIa clinical trials as a cognitive enhancer. It also showed profound antiparkinson effects in MPTP-treated primates, but caused profound hypotension in one early clinical trial in [Parkinson's disease](https://en.wikipedia.org/wiki/Par" attribution: sources:
  • name: "dopamine.club" role: "community aggregate stats, dose distribution, stack synergies, AI-seeded interactions" url: "https://dopamine.club/substances/skf-38393/"
  • name: "reddit" role: "paragraph-level community anecdotes" url: "https://reddit.com" text: "Aggregated from creator-curated and community sources. Verify dose, sourcing, and safety before use."

=== community-data-block:end ===

• Dihydrexidine derivatives

• A-86929 - full agonist with 14-fold selectivity for D1-like receptors over D2

• Dihydrexidine - full agonist with 10-fold selectivity for D1-like receptors over D2 that has been in Phase IIa clinical trials as a cognitive enhancer. It also showed profound antiparkinson effects in MPTP-treated primates, but caused profound hypotension in one early clinical trial in [Parkinson's disease](https://en.wikipedia.org/wiki/Par" attribution: sources:
  • name: "dopamine.club" role: "community aggregate stats, dose distribution, stack synergies, AI-seeded interactions" url: "https://dopamine.club/substances/skf-38393/"
  • name: "reddit" role: "paragraph-level community anecdotes" url: "https://reddit.com" text: "Aggregated from creator-curated and community sources. Verify dose, sourcing, and safety before use."

=== community-data-block:end ===