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Bakuchiol
Plant-derived "natural retinol alternative".
Aliases (3)
meroterpene phenol from Psoralea corylifolia · Babchi seed extract · Bidens pilosa source
TYPICAL DOSE
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ROUTE
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CYCLE
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STORAGE
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Overview
What is Bakuchiol?
Plant-derived "natural retinol alternative". Single head-to-head RCT showed equivalence to 0.5% retinol with less irritation. Daytime + vitamin-C compatible. OPTIONAL-ADD.
What to Expect
- Week 1Tolerability and dose-response.
- Week 2-4Early effect window.
- Week 4-8Peak benefit assessment.
- Week 8+Cycle decision point.
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Related compounds
Cross-referenced from BakuchiolRetinol
OTHER
Supplement
LOW
Retinaldehyde
OPTIONAL-ADD
Mid-strength topical retinoid. One enzymatic step from retinoic acid (the active form): skin retinol dehydrogenase converts retinal → retinoic acid. Faster + more potent than retinol; less irritating than tretinoin.
HIGH
Tretinoin (all-trans retinoic acid)
OPTIONAL-ADD
First-generation topical retinoid (RAR pan-agonist); endogenous active metabolite of retinol (vitamin A)
HIGH
Adapalene
OPTIONAL-ADD
Third-generation synthetic retinoid (naphthoic acid derivative). Selective RAR-β/γ agonism. FDA-approved 1996 (Rx); 0.1% became OTC in 2016. Standard-of-care for mild-moderate acne.
HIGH
Niacinamide
OPTIONAL-ADD
Vitamin B3 — amide form (NAD+ precursor)
MEDIUM
Vitamin C
OPTIONAL-ADD
Supplement
HIGH
Hyaluronic Acid
OPTIONAL-ADD
"Glycosaminoglycan (GAG) — non-sulfated linear polysaccharide; oral nutraceutical / intra-articular Rx viscosupplement / topical dermal cosmeceutical / ophthalmic Rx"
MEDIUM