This page describes pharmacological agents that may have legal restrictions, side effects, and drug interactions in your jurisdiction. Information is for educational research only — consult a clinician before considering any compound.

High-risk compound

Surface here is educational only; do not use without medical supervision. Our editorial verdict is SKIP-FOR-NOW — current cost / risk / redundancy puts it below the line.

Mitragynine

Primary kratom alkaloid.

Aliases (3)

mitragyna alkaloid · primary kratom alkaloid · isolated mitragynine

TYPICAL DOSE

—

ROUTE

—

CYCLE

—

STORAGE

—

Overview

What is Mitragynine?

Primary kratom alkaloid. G-protein-biased μ-opioid partial agonist. Isolated extracts have higher overdose + dependence risk than whole-leaf kratom. SKIP-FOR-NOW.

What to Expect

Week 1
Tolerability and dose-response.
Week 2-4
Early effect window.
Week 4-8
Peak benefit assessment.
Week 8+
Cycle decision point.

Was this helpful?

Your feedback shapes what we research deeper.

How was your experience with this compound?

Anonymous · one vote per session · results below at 5+ votes.

Loading…

✎

See something off?

Most of this wiki is AI-generated. Suggest a correction, dosing update, or new evidence — we review every submission.

Discussion — click to load ▸

Loading…

Continue: Extended research →

Our verdict, decision matrix, deep dives, controversies, sources

Related compounds

Cross-referenced from Mitragynine

7-OH-Mitragynine

Minor kratom alkaloid (~2% of leaf alkaloid content) and major metabolite of mitragynine in humans via CYP3A4. Much higher μ-opioid affinity than mitragynine (~10-46× depending on assay). Functionally a moderate-strength opioid agonist.

O-Desmethyltramadol

Active opioid metabolite of tramadol. Generated by CYP2D6 hepatic O-demethylation. ~200× higher μ-opioid receptor affinity than parent tramadol. Sold as research chemical in isolated form for euphoric / analgesic effects.

Atypical antidepressant (Servier 1983) — functionally a μ-opioid + δ-opioid agonist