This page describes pharmacological agents that may have legal restrictions, side effects, and drug interactions in your jurisdiction. Information is for educational research only — consult a clinician before considering any compound.

High-risk compound

Surface here is educational only; do not use without medical supervision. Our editorial verdict is SKIP-PERMANENT — risk:benefit fails for the canonical archetype.

O-Desmethyltramadol

Tramadol's active opioid metabolite, isolated.

Aliases (4)

O-DSMT · M1 (tramadol metabolite) · tramadol M1 · (+)-O-desmethyltramadol

TYPICAL DOSE

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ROUTE

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CYCLE

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STORAGE

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Overview

What is O-Desmethyltramadol?

Tramadol's active opioid metabolite, isolated. Bypasses the CYP2D6 metabolic safety gate. Same overdose + dependence risk as other moderate opioids. SKIP-PERMANENT.

What to Expect

Week 1
Tolerability and dose-response.
Week 2-4
Early effect window.
Week 4-8
Peak benefit assessment.
Week 8+
Cycle decision point.

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Related compounds

Cross-referenced from O-Desmethyltramadol

Primary indole alkaloid of Mitragyna speciosa (kratom). Comprises ~60-66% of total alkaloid content in dried leaf. Functionally a partial μ-opioid agonist + α2-adrenergic agonist + 5-HT2A partial agonist.

7-OH-Mitragynine

Minor kratom alkaloid (~2% of leaf alkaloid content) and major metabolite of mitragynine in humans via CYP3A4. Much higher μ-opioid affinity than mitragynine (~10-46× depending on assay). Functionally a moderate-strength opioid agonist.